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首页> 外文期刊>Behavioural Brain Research: An International Journal >Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box.
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Anxiolytic and anxiogenic drug effects on male and female gerbils in the black-white box.

机译：黑白盒子中的抗焦虑和抗焦虑药物对雄性和雌性沙鼠的作用。

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摘要

Neurokinin-1, (NK1) receptor antagonists offer strong potential as anxiolytic drugs with few side effects. The use of the Mongolian gerbil for anxiety research offers advantages because gerbil NK1 receptors share a greater homology with human NK1 receptors than those of other rodents. Studies are needed to validate existing tests of anxiety for use with this species. This study examined the effects of two anxiolytics (buspirone and diazepam) and two anxiogenics (caffeine and FG142) on male and female gerbil behaviour in the black-white box (BWB). Diazepam was anxiolytic in males but not females. The anxiolytic effects of buspirone were apparent at the lower doses in both males and females. Higher doses resulted in sedative effects in both sexes. Caffeine produced mild anxiogenesis in females at the lowest dose, and in males at the highest dose. FG7142 was mildly anxiogenic in males and not at all in females. Findings are discussed in light of previous research. The gerbil BWB should not be used as a valid test of anxiety in its current form.
机译：Neurokinin-1（NK1）受体拮抗剂作为抗焦虑药具有强大的潜力，几乎没有副作用。使用蒙古沙鼠进行焦虑研究具有优势，因为沙鼠NK1受体与人NK1受体的同源性比其他啮齿动物更大。需要进行研究以验证用于该物种的现有焦虑测试。这项研究检查了两种抗焦虑药（丁螺环酮和地西epa）和两种抗焦虑药（咖啡因和FG142）对黑白盒子（BWB）中男性和女性沙鼠行为的影响。地西p对男性有抗焦虑作用，但对女性无抗焦虑作用。在男性和女性的较低剂量下，丁螺环酮的抗焦虑作用都很明显。较高的剂量会导致两性的镇静作用。咖啡因在最低剂量的雌性和最高剂量的雄性中产生轻度的血管生成。 FG7142在男性中轻度焦虑，而在女性中则完全没有。根据先前的研究讨论了发现。沙鼠BWB不应以当前形式用作有效的焦虑测试。

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