• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of biochemical and molecular toxicology >The systemic inflammatory response syndrome in acute antipsychotic poisoning
【24h】

The systemic inflammatory response syndrome in acute antipsychotic poisoning

机译：急性抗精神病毒中毒中的全身炎症反应综合征

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study was to investigate the mutual effect of systemic inflammatory response syndrome (SIRS) accompanied with fibrinolysis, endotoxemia, and coagulation in severe cases of antipsychotic poisoning. A total of 199 patients were examined, of which 71 were men and 128 were women. The age of the patients was from 22 to 63 years, (45.3 ± 6.1 years on average). According to the results of the course of therapy, the patients were divided into two groups. In the blood plasma, the content of C-reactive protein, fibrinogen and its proteolysis products (oligopeptides, D-dimers), interleukin-6 were determined. In the first 1 to 3 days, in group 1, the level of interleukin-6 decreased and approached the normal level (P < .05). The opposite trend continued throughout the observation of patients from group 2—their levels of interleukin-6 increased day by day (P<.05). The concentration of D-dimer already in 1 day after admission to intensive care in patients from group 2 exceeded the norm by 14 times (P< .05). The level of D-dimer correlated with the level of oligopeptides in blood plasma upon admission, as well as for 3 and 5 days after admission to intensive care: 0.36, 0.76 at P< .05, 0.94 at P< .01, respectively. Similar correlations were obtained for the content of oligopeptides in urine and the level of D-dimer: 0.55, 0.85 at P < .05, 0.93 at P < .01. In this regard, the most pronounced correlation is that between the SIRS score, plasma D-dimer level, and the plasma level of the D-dimer derivatives, oligopeptides.
机译：本研究旨在探讨全身炎症反应综合征（SIRS）伴纤维蛋白溶解、内毒素血症和凝血在严重抗精神病药中毒病例中的相互作用。共检查了199名患者，其中71名为男性，128名为女性。患者年龄22～63岁（平均45.3±6.1岁）。根据疗程结果，将患者分为两组。测定血浆中C-反应蛋白、纤维蛋白原及其蛋白水解产物（寡肽、D-二聚体）、白细胞介素-6的含量。在第1至3天，第1组的白细胞介素-6水平下降并接近正常水平（P<0.05）。在对第2组患者的整个观察过程中，相反的趋势持续存在——他们的白细胞介素-6水平一天比一天高（P<0.05）。第2组患者入院后1天内的D-二聚体浓度超过正常值14倍（P<0.05）。D-二聚体水平与入院时以及入院后3天和5天血浆中的寡肽水平相关：分别为0.36、0.76（P<0.05）和0.94（P<0.01）。尿中寡肽含量与D-二聚体水平之间也存在类似的相关性：P<0.05时为0.55，P<0.85，P<0.01时为0.93。在这方面，最显著的相关性是SIRS评分、血浆D-二聚体水平和血浆D-二聚体衍生物寡肽水平之间的相关性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号