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首页> 外文期刊>Journal of biochemical and molecular toxicology >Enhanced anticancer potency of doxorubidn in combination with curcumin in gastric adenocarcinoma
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Enhanced anticancer potency of doxorubidn in combination with curcumin in gastric adenocarcinoma

机译：增强多柔枯的抗癌效力与姜黄素组合在胃腺癌中的组合

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Gastric cancer (GC) is one of the prevalent human malignancies and the third most common cause of cancer-related death worldwide. The doxorubicin hydrochloride is one of the important chemotherapeutic anticancer agents, with a limited therapeutic efficacy for treatment of GC. Therefore, taking advantage of synergistic effects by strategies like combination therapy seems appropriate and promising in treatment of GC. The aim of this study was to investigate a novel method to enhance the therapeutic efficacy of doxorubicin (as a chemotherapeutic agent) by co-administration of curcumin (as a bioactive herbal compound) in GC treatment. In the present study, the effects of curcumin, doxorubicin, and their combinations (Dox-Cur) were evaluated on the viability, morphological features, tumor spheroid formation, migration, invasion, and apoptosis of gastric adenocarcinoma cell line (AGS). Moreover, expression levels of BAX, BCL-2, and CASP9 genes were assessed among AGS cells treated with curcumin, doxorubicin, and Dox-Cur. The obtained results showed that all of curcumin, doxorubicin, and Dox-Cur treatments significantly decreased the viability, tumor spheroid formation, migration, and invasion in the GC model cells. Furthermore, apoptosis rates in AGS cells were increased in a concentration- and time-dependent manner in all of the treatment groups. Moreover, the anticancer activity of the Dox-Cur combination was significantly more than curcumin and doxorubicin treatments alone. According to the results, Dox-Cur combination therapy exerts more profound apoptotic and anticancer effects on the AGS cell line than curcumin or doxorubicin monotherapy.
机译：胃癌是人类最常见的恶性肿瘤之一，也是全球第三大癌症相关死亡原因。盐酸阿霉素是一种重要的化疗抗癌药物，对GC的治疗效果有限。因此，利用联合治疗等策略的协同效应似乎是治疗GC的合适且有希望的方法。本研究的目的是探索一种新的方法，通过在GC治疗中联合施用姜黄素（作为一种生物活性草药化合物）来提高阿霉素（作为一种化疗药物）的治疗效果。在本研究中，评估了姜黄素、阿霉素及其组合（Dox-Cur）对胃腺癌细胞系（AGS）的活力、形态学特征、肿瘤球体形成、迁移、侵袭和凋亡的影响。此外，在用姜黄素、阿霉素和多柔比星治疗的AGS细胞中评估BAX、BCL-2和CASP9基因的表达水平。结果表明，所有姜黄素、阿霉素和阿霉素治疗均显著降低了GC模型细胞的活力、肿瘤球体的形成、迁移和侵袭。此外，在所有治疗组中，AGS细胞的凋亡率均以浓度和时间依赖性的方式增加。此外，与姜黄素和阿霉素单独治疗相比，阿霉素-姜黄素联合治疗的抗癌活性显著更高。根据研究结果，与姜黄素或阿霉素单药治疗相比，Dox-Cur联合治疗对AGS细胞系具有更深远的凋亡和抗癌作用。

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