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首页> 外文期刊>Journal of biochemical and molecular toxicology >Modulation of antioxidant enzymes, SIRT1 and NF-κB by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma
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Modulation of antioxidant enzymes, SIRT1 and NF-κB by resveratrol and nicotinamide in alcohol-aflatoxin B1-induced hepatocellular carcinoma

机译：白藜芦醇和烟草中抗氧化酶，SIRT1和NF-κB的调节醇 - 黄曲霉毒素B1诱导的肝细胞癌

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摘要

Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and is associated with poor prognosis. The current study aimed to assess the therapeutic efficacy of resveratrol when administered alone and in combination with nicotinamide against alcohol-aflatoxin B1-induced HCC. Results reveal that during the development and progression of cancer, there was a decline in the level of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase (GR), antioxidant glutathione, and glutathione S-transferase, which is an enzyme of detoxification pathways. Treatment of resveratrol restored the level of catalase and glutathione peroxidase toward normal in alcohol-aflatoxin B1-induced HCC; however, nicotinamide worked in concert with resveratrol only in upregulating the activity of glutathione reductase, glutathione level, and glutathione S-transferase. SIRT1 agonist resveratrol was observed to modulate the activity of antioxidant enzymes by negatively regulating the expression of nuclear factor-κB (NF-κB) in alcohol-aflatoxin B1-induced HCC, thereby suggesting a cross-talk between antioxidant enzymes SIRT1 and NF-κB during the development and progression of HCC and its therapeutics by resveratrol and nicotinamide.
机译：肝细胞癌（HCC）是全球第五大最常见的癌症，与不良预后相关。目前的研究旨在评估白藜芦醇单独或联合烟酰胺治疗酒精黄曲霉毒素B1诱导的肝癌的疗效。结果显示，在癌症的发展和进展过程中，抗氧化酶过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶（GR）、抗氧化酶谷胱甘肽和谷胱甘肽S-转移酶（一种解毒途径的酶）水平下降。白藜芦醇使乙醇黄曲霉毒素B1诱导的肝癌中过氧化氢酶和谷胱甘肽过氧化物酶水平恢复正常；然而，烟酰胺仅在上调谷胱甘肽还原酶活性、谷胱甘肽水平和谷胱甘肽S-转移酶方面与白藜芦醇协同作用。在酒精黄曲霉毒素B1诱导的HCC中，观察到SIRT1激动剂白藜芦醇通过负性调节核因子-κB（NF-κB）的表达来调节抗氧化酶的活性，从而表明抗氧化酶SIRT1和NF-κB在HCC的发展和进展过程中相互作用，以及白藜芦醇和烟酰胺的治疗作用。

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