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首页> 外文期刊>Journal of biochemical and molecular toxicology >ERp29 affects the migratory and invasive ability of human extravillous trophoblast HTR-8/SVneo cells via modulating the epithelial-mesenchymal transition
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ERp29 affects the migratory and invasive ability of human extravillous trophoblast HTR-8/SVneo cells via modulating the epithelial-mesenchymal transition

机译：ERP29通过调节上皮 - 间充质转换来影响人外形滋养细胞HTR-8 / SVNEO细胞的迁移和侵袭能力

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摘要

Dysfunction of trophoblast metastasis into the endometrium is the main cause of pre-eclampsia (PE); however, the factors affecting this process are still unclear. In this study, we found that endoplasmic reticulum protein 29 (ERp29), one molecular chaperone of the endoplasmic reticulum, was aberrantly upregulated in the placenta of pre-eclamptic patients compared with healthy controls. Then, an in vitro study using human extravillous trophoblast HTR-8/SVneo cells showed that ERp29 upregulation could inhibit the migratory and invasive ability of HTR-8/SVneo cells, while ERp29 downregulation had the opposite effect. Mechanical experiments confirmed that ERp29 blocked trophoblast metastasis via inhibiting the process of epithelial-mesenchymal transition and affecting the Wnt/β-catenin signaling pathway. In conclusion, this study revealed the important role of ERp29 in trophoblast metastasis and improved the mechanical understanding of PE occurrence.
机译：滋养层细胞向子宫内膜转移功能障碍是子痫前期（PE）的主要原因；然而，影响这一过程的因素仍不清楚。在这项研究中，我们发现，与健康对照组相比，先兆子痫患者的胎盘内质网蛋白29（ERp29）异常上调，ERp29是内质网的一种分子伴侣。然后，利用人类绒毛外滋养层HTR-8/SVneo细胞进行的体外研究表明，ERp29上调可抑制HTR-8/SVneo细胞的迁移和侵袭能力，而ERp29下调则具有相反的效果。力学实验证实，ERp29通过抑制上皮-间质转化过程和影响Wnt/β-连环蛋白信号通路阻断滋养细胞转移。总之，本研究揭示了ERp29在滋养细胞转移中的重要作用，并提高了对PE发生的机械理解。

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