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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Magnesium alloy AZ91 exhibits antimicrobial properties in vitro but not in vivo
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Magnesium alloy AZ91 exhibits antimicrobial properties in vitro but not in vivo

机译：镁合金AZ91在体外展示抗菌性质，但不含体内抗菌性质

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摘要

Magnesium alloys hold great promise for developing orthopedic implants that are biocompatible, biodegradable, and mechanically similar to bone tissue. This study evaluated the in vitro and in vivo antimicrobial properties of magnesium-9%aluminum-1%zinc (AZ91) and commercially pure titanium (cpTi) against Acinetobacter baumannii (Ab307). The in vitro results showed that as compared to cpTi, incubation with AZ91 significantly reduced both the planktonic (cpTi=3.45e8, AZ91=8.97e7, p0.001) colony forming units (CFU) and biofilm-associated (cpTi=3.89e8, AZ91=1.78e7, p=0.01) CFU of Ab307. However, in vivo results showed no significant differences in the CFU enumerated from the cpTi and AZ91 implants following a 1-week implantation in an established rodent model of Ab307 implant associated infection (cpTi=5.23e3, AZ91=2.46e3, p=0.29). It is proposed that the in vitro results were associated with an increased pH in the bacterial culture as a result of the AZ91 corrosion process. The robust in vivo buffering capacity likely diminished this corrosion associated pH antimicrobial effect. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 221-227, 2018.
机译：镁合金在开发生物相容性好、可生物降解、机械性能与骨组织相似的骨科植入物方面有着巨大的前景。本研究评估了镁-9%铝-1%锌（AZ91）和商用纯钛（cpTi）对鲍曼不动杆菌（Ab307）的体外和体内抗菌性能。体外试验结果表明，与cpTi相比，AZ91培养显著降低了Ab307的浮游（cpTi=3.45e8，AZ91=8.97e7，p；0.001）菌落形成单位（CFU）和生物膜相关（cpTi=3.89e8，AZ91=1.78e7，p=0.01）CFU。然而，体内结果显示，在已建立的Ab307植入物相关感染啮齿动物模型中植入1周后，cpTi和AZ91植入物的CFU计数没有显著差异（cpTi=5.23e3，AZ91=2.46e3，p=0.29）。有人提出，体外试验结果与AZ91腐蚀过程导致的细菌培养物pH值升高有关。强大的体内缓冲能力可能会减弱这种与腐蚀相关的pH值抗菌效应。（c） 2017威利期刊有限公司《生物医学材料研究》B部分：Appl Biomater，106B:221-227，2018年。

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