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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Magnesium alloy AZ91 exhibits antimicrobial properties in vitro but not in vivo
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Magnesium alloy AZ91 exhibits antimicrobial properties in vitro but not in vivo

机译：镁合金AZ91在体外展示抗菌性质，但不含体内抗菌性质

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摘要

Magnesium alloys hold great promise for developing orthopedic implants that are biocompatible, biodegradable, and mechanically similar to bone tissue. This study evaluated the in vitro and in vivo antimicrobial properties of magnesium-9%aluminum-1%zinc (AZ91) and commercially pure titanium (cpTi) against Acinetobacter baumannii (Ab307). The in vitro results showed that as compared to cpTi, incubation with AZ91 significantly reduced both the planktonic (cpTi=3.45e8, AZ91=8.97e7, p0.001) colony forming units (CFU) and biofilm-associated (cpTi=3.89e8, AZ91=1.78e7, p=0.01) CFU of Ab307. However, in vivo results showed no significant differences in the CFU enumerated from the cpTi and AZ91 implants following a 1-week implantation in an established rodent model of Ab307 implant associated infection (cpTi=5.23e3, AZ91=2.46e3, p=0.29). It is proposed that the in vitro results were associated with an increased pH in the bacterial culture as a result of the AZ91 corrosion process. The robust in vivo buffering capacity likely diminished this corrosion associated pH antimicrobial effect. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 221-227, 2018.
机译：镁合金对开发生物相容性，可生物降解和机械类似的骨组织的整形外科植入物具有很大的希望。该研究评估了镁-9％铝-1％锌（AZ91）和商业纯钛（CPTI）的体外和体内抗微生物性能，对抗血管杆菌（AB307）。体外结果表明，与CPTI相比，与AZ91的孵育显着减少了浮游（CPTI = 3.45E8，AZ91 = 8.97E7，P <0.001）菌落形成单元（CFU）和生物膜相关（CPTI = 3.89e8， AZ91 = 1.78E7，P = 0.01）AB307的CFU。然而，在体内结果表明，在AB307植入物相关感染的已建立的啮齿动物模型中，CPTI和AZ91植入物中的CFU中没有显着差异（CPTI = 5.23E3，AZ91 = 2.46E3，P = 0.29） 。提出，由于AZ91腐蚀过程，体外结果与细菌培养中的pH值增加相关。体内缓冲能力的稳健可能降低了这种腐蚀相关的pH抗微生物效果。 （c）2017 Wiley期刊，Inc。J生物保解率B：苹果生物摩特，106B：221-227,2018。

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