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首页> 外文期刊>Behavioural pharmacology >Beneficial effects of chronic oxytocin administration and social co-housing in a rodent model of post-traumatic stress disorder
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Beneficial effects of chronic oxytocin administration and social co-housing in a rodent model of post-traumatic stress disorder

机译：在创伤后应激障碍的啮齿动物模型中，长期服用催产素和社交共居的有益影响

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摘要

Post-traumatic stress disorder (PTSD) is in part due to a deficit in memory consolidation and extinction. Oxytocin (OXT) has anxiolytic effects and promotes prosocial behaviors in both rodents and humans, and evidence suggests that it plays a role in memory consolidation. We studied the effects of administered OXT and social co-housing in a rodent model of PTSD. Acute OXT yielded a short-term increase in the recall of the traumatic memory if administered immediately after trauma. Low doses of OXT delivered chronically had a cumulating anxiolytic effect that became apparent after 4 days and persisted. Repeated injections of OXT after short re-exposures to the trauma apparatus yielded a long-term reduction in anxiety. Co-housing with naive nonshocked animals decreased the memory of the traumatic context compared with single-housed animals. In the long term, these animals showed less thigmotaxis and increased interest in novel objects, and a low OXT plasma level. Co-housed PTSD animals showed an increase in risk-taking behavior. These results suggest beneficial effects of OXT if administered chronically through increases in memory consolidation after re-exposure to a safe trauma context. We also show differences between the benefits of social co-housing with naive rats and co-housing with other shocked animals on trauma-induced long-term anxiety. (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
机译：创伤后应激障碍（PTSD）部分归因于记忆巩固和消退的缺乏。催产素（OXT）具有抗焦虑作用，并促进啮齿动物和人类的亲社会行为，证据表明它在记忆巩固中起作用。我们研究了在PTSD的啮齿动物模型中施用OXT和社会共居的影响。如果在创伤后立即给药，急性OXT会在短期内增加创伤记忆的回忆。长期递送的低剂量OXT具有累积的抗焦虑作用，这种作用在4天后变得明显并持续存在。短暂再暴露于创伤器械后重复注射OXT，可长期减轻焦虑。与单笼动物相比，与幼稚的非震惊动物合住会减少对创伤情境的记忆。从长远来看，这些动物表现出较少的趋轴性，并且对新颖物体的兴趣增加，并且OXT血浆水平较低。共同饲养的PTSD动物表现出冒险行为增加。这些结果表明，如果长期暴露于安全的创伤后，通过增加记忆巩固来长期给药，OXT会产生有益的作用。我们还显示了与天真的大鼠进行社会共居和与其他震惊的动物对因创伤造成的长期焦虑共居的好处之间的差异。 （C）2016 Wolters Kluwer Health，Inc.保留所有权利。

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