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首页> 外文期刊>Annals of thoracic and cardiovascular surgery: official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia >Experimental study of pegylated liposomal hemoglobin on norepinephrine release and reperfusion arrhythmias in isolated Guinea pig hearts.
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Experimental study of pegylated liposomal hemoglobin on norepinephrine release and reperfusion arrhythmias in isolated Guinea pig hearts.

机译：聚乙二醇脂质体血红蛋白对离体豚鼠心脏去甲肾上腺素释放和再灌注心律不齐的实验研究。

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PURPOSE: Under myocardial reperfusion conditions, hemoglobin (Hb)-based artificial blood showed effectiveness for post-ischemic dysfunction. However, there are no studies about the effects of this product on reperfusion arrhythmias (ventricular fibrillation, VF) associated with norepinephrine (NE) release. This study was to evaluate the effects of the timing of the administration of pegylated liposomal Hb (LHb, P(50)=40-45 mmHg, 1 mg/mL) on NE release and VF. MATERIALS AND METHODS: Isolated guinea pig hearts (n=6 in each group) were randomly divided into four groups in Krebs-Henseleit solution being supplemented or not with LHb as follows: pre-ischemia (PRE), reperfusion (REP), or PRE+REP groups. The hearts were perfused for 30 min (preischemic period) and then subjected to 30 min of global ischemia, followed by 30 min of reperfusion with a normothermic Langendorff apparatus at 30 mm Hg aortic pressure in a constant pressure model. RESULTS: No differences were documented among the four groups in heart rate, left ventricular-developed pressure, or coronary flow rate. However, the REP group significantly decreased the duration of VF and NE release, but it did not inhibit the incidence of VF. CONCLUSION: These results suggest that the administration of LHb, especially with the timing of reperfusion, might prevent reperfusion arrhythmias linked to the inhibition of NE release.
机译：目的：在心肌再灌注条件下，基于血红蛋白（Hb）的人造血显示出对缺血后功能障碍的有效性。但是，尚无有关此产品对与去甲肾上腺素（NE）释放相关的再灌注性心律不齐（室颤，VF）的影响的研究。这项研究旨在评估聚乙二醇化脂质体Hb（LHb，P（50）= 40-45 mmHg，1 mg / mL）给药时间对NE释放和VF的影响。材料与方法：将分离的豚鼠心脏（每组n = 6）随机分为四组，分别补充或不补充LHb：缺血前（PRE），再灌注（REP）或PRE + REP组。在恒定压力模型中，将心脏灌注30分钟（缺血前期），然后进行30分钟的整体缺血，然后使用常温Langendorff仪器在30 mm Hg主动脉压力下再灌注30分钟。结果：四组之间在心率，左心室发育压力或冠状动脉流速方面没有差异。但是，REP组显着降低了VF和NE释放的持续时间，但并未抑制VF的发生。结论：这些结果表明，LHb的给药，尤其是与再灌注的时机，可以预防与NE释放抑制有关的再灌注心律不齐。

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