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Quantification of DNA methylation and hydroxymethylation in Alzheimer's disease mouse model using LC‐MS/MS

机译：使用LC-MS / MS的Alzheimer疾病小鼠模型中DNA甲基化和羟甲基甲基化的定量

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Abstract >Ambiguous alteration patterns of 5‐methylcytosine (5mC) and 5‐hydroxymethylcytosine (5hmC) involved in Alzheimer's disease (AD) obstructed the mechanism investigation of this neurological disorder from epigenetic view. Here, we applied a fully quantitative and validated LC‐MS/MS method to determine genomic 5mC and 5hmC in the brain cortex of 3 month‐aged (12, 15, and 18?month) AD model mouse and found significant increases of 5mC and 5hmC levels in different months of AD mouse when compared with age‐matched wild‐type control and exhibited rising trend from 12‐month to 18‐month?AD mouse, thereby supporting genomic DNA methylation and hydroxymethylation were positively correlated with developing AD. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns=”http://www.wiley.com/namespaces/wiley“type=“main”xml:lang=“en”><title type=“main”>摘要>阿尔茨海默病（AD）中5-甲基胞嘧啶（5mC）和5-羟甲基胞嘧啶（5hmC）的模糊改变模式阻碍了从表观遗传学角度对这种神经系统疾病的机制研究。在这里，我们应用了一种完全定量且经过验证的LC-MS/MS方法来测定3个月龄（12、15和18个月）AD模型小鼠大脑皮层中的基因组5mC和5hmC，发现与年龄匹配的野生型对照组相比，不同月龄的AD小鼠的5mC和5hmC水平显著增加，并且从12个月到18个月呈上升趋势？因此支持基因组DNA甲基化和羟甲基化的AD小鼠与AD的发生呈正相关。</abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-34906/'>《Journal of mass spectrometry: JMS》</a> <b style="margin: 0 2px;">|</b><span>2018年第7期</span><b style="margin: 0 2px;">|</b><span>共5页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Huang Qionglin&option=202" target="_blank" rel="nofollow">Huang Qionglin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Xu Simin&option=202" target="_blank" rel="nofollow">Xu Simin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mo Mingming&option=202" target="_blank" rel="nofollow">Mo Mingming;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Yang Qingjin&option=202" target="_blank" rel="nofollow">Yang Qingjin;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Li Jian&option=202" target="_blank" rel="nofollow">Li Jian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhong Yu&option=202" target="_blank" rel="nofollow">Zhong Yu;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Junjie&option=202" target="_blank" rel="nofollow">Zhang Junjie;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zhang Lijian&option=202" target="_blank" rel="nofollow">Zhang Lijian;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ye Xiaoxiao&option=202" target="_blank" rel="nofollow">Ye Xiaoxiao;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Liu Zhou&option=202" target="_blank" rel="nofollow">Liu Zhou;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cai Chun&option=202" target="_blank" rel="nofollow">Cai Chun;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Institute of Neurology Affiliated HospitalGuangdong Medical UniversityZhanjiang 524001 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> <p>Institute of Neurology Affiliated HospitalGuangdong Medical UniversityZhanjiang 524001 China;</p> <p>Analysis CenterGuangdong Medical UniversityZhanjiang 524023 China;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Alzheimer's disease&option=203" rel="nofollow">Alzheimer's disease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=DNA methylation&option=203" rel="nofollow">DNA methylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hydroxymethylation&option=203" rel="nofollow">hydroxymethylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=LC‐MS/MS&option=203" rel="nofollow">LC‐MS/MS;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mouse model&option=203" rel="nofollow">mouse model;</a> </p> <div class="translation"> 机译：None; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div 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WANG Qi</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=XIANG Huan&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,XIANG Huan</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ZHAO Hui-liang&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,ZHAO Hui-liang</a> <span> <a href="/journal-cn-6428/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国药理学与毒理学杂志 </a> </span> <span> . 2021</span><span>,第010期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_chinese-nerve-regeneration-research-english-version_thesis/0201298711728.html">DNA vaccines targeting amyloid-βoligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sha Sha&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 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