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首页> 外文期刊>Journal of oral rehabilitation >The effect of botulinum toxin A on patients with persistent idiopathic dentoalveolar pain-A systematic review
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The effect of botulinum toxin A on patients with persistent idiopathic dentoalveolar pain-A systematic review

机译：肉毒杆菌毒素A对持续性发作性心脏肺泡疼痛的患者的影响 - 系统综述

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Background It has been suggested that botulinum toxin A (BONT-A) is a safe and effective treatment in relieving pain in patients with persistent idiopathic dentoalveolar pain (PIDP). Objectives This study aimed to systematically evaluate all the available studies investigating the pain-relieving effects of BONT-A in patients with PIDP. Methods A systematic search with specific search terms was made in PubMed, Web of Science and Scopus. Two authors screened titles and abstracts and selected eligible studies for inclusion in the systematic review. The quality of the studies was evaluated by the 12 items Quality Assessment Tool for Observational studies (Pre-Post) Studies with No Control Group, and the level of evidence was assessed according to GRADE. Results Three observational studies of 3695 identified were included (445 overlapping studies; 3247 excluded studies). All studies were uncontrolled observational studies investigating the pain-relieving effect of BONT-A in patients with PIDP. The included studies had a fair quality (moderate risk of bias) and insufficient level of evidence. The pain reducing effect by BONT-A injections was in average 50% or more in two studies, in one study 3 out of 4 patients became almost pain free. Conclusions This systematic review shows that presently the level of scientific evidence is insufficient to evaluate the pain-relieving effect of BONT-A injections in patients with PIDP. There are indications that BONT-A injections could be a possible management option for patients with PIDP that seems to be safe and with few adverse events. There is a need for well-designed placebo-controlled, double-blind RCTs.
机译：背景研究表明，A型肉毒毒素（BONT-A）是缓解持续性特发性牙槽痛（PIDP）患者疼痛的安全有效的治疗方法。目的本研究旨在系统地评估所有关于BONT-A缓解PIDP患者疼痛效果的现有研究。方法在PubMed、Web of Science和Scopus上进行系统搜索，并给出具体搜索词。两位作者筛选了标题和摘要，并选择了符合条件的研究纳入系统评价。在没有对照组的情况下，采用观察性研究（前后）的12项质量评估工具评估研究的质量，并根据等级评估证据水平。结果共纳入3695项观察研究（445项重叠研究；3247项排除研究）。所有研究均为非对照观察性研究，旨在调查BONT-A对PIDP患者的止痛效果。纳入的研究质量一般（存在中度偏倚风险），证据不足。在两项研究中，BONT-A注射的止痛效果平均为50%或以上，在一项研究中，四分之三的患者几乎没有疼痛。结论本系统综述显示，目前的科学证据水平不足以评估BONT-A注射液对PIDP患者的镇痛效果。有迹象表明，BONT-A注射可能是PIDP患者的一种可能的治疗选择，似乎是安全的，且几乎没有不良事件。需要设计良好的安慰剂对照双盲随机对照试验。

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