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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Prevalence and Correlates of Intracranial Atherosclerotic Disease Among Community-Dwelling Older Adults of Amerindian Ancestry. The Three Villages Study
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Prevalence and Correlates of Intracranial Atherosclerotic Disease Among Community-Dwelling Older Adults of Amerindian Ancestry. The Three Villages Study

机译：美洲印第安人血统社区住宅老年人颅内动脉粥样硬化疾病的患病率及相关性。 三个村庄的研究

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Background: Knowledge on the prevalence and correlates of intracranial atherosclerotic disease (ICAD) is limited. We aimed to assess prevalence, clinical and neuroimaging correlates of ICAD in a cohort of older adults of Amerindian ancestry. Methods: The study included 581 community-dwellers aged >= 60 years (mean age 71 +/- 8.4 years; 57% women) living in rural Ecuadorian villages. ICAD was identified by means of CT determinations of carotid siphon calcifications (CSC) or MRA findings of significant stenosis of intracranial arteries. Fully-adjusted logistic regression models were fitted with biomarkers of ICAD as the dependent variables. Results: A total of 205 (35%) of 581 participants had ICAD, including 185 with high calcium content in the carotid siphons and 40 with significant stenosis of at least one intracranial artery (20 subjects had both biomarkers). Increasing age, high fasting blood glucose, >10 enlarged basal ganglia-perivascular spaces and non-lacunar strokes were associated with high calcium content in the carotid siphons. In contrast, male gender, moderate-to-severe white matter hyperintensities, lacunar and non-lacunar strokes were associated with significant stenosis of intracranial arteries. Stroke was more common among subjects with any biomarker of ICAD than in those with no biomarkers (29% versus 9%, p < 0.001). Significant stenosis of intracranial arteries was more often associated with stroke than high calcium content in the carotid siphons, suggesting that CSC are more likely an ICAD biomarker than causally related to stroke. Conclusions: ICAD prevalence in Amerindians is high, and is significantly associated with stroke. CSC and significant stenosis of intracranial arteries may represent different phenotypes of ICAD. (c) 2020 Elsevier Inc. All rights reserved.
机译：背景：关于颅内动脉粥样硬化性疾病（ICAD）的患病率及其相关因素的知识有限。我们的目的是评估美洲印第安人血统的老年人群体中ICAD的患病率、临床和神经影像学相关性。方法：该研究包括581名居住在厄瓜多尔农村的60岁以上社区居民（平均年龄71+/-8.4岁；57%为女性）。ICAD通过颈动脉虹吸钙化（CSC）的CT测定或颅内动脉显著狭窄的MRA发现来确定。以ICAD的生物标志物作为因变量，对完全调整的逻辑回归模型进行拟合。结果：581名参与者中共有205人（35%）患有ICAD，其中185人颈动脉虹吸中钙含量高，40人至少有一条颅内动脉明显狭窄（20名受试者同时具有两种生物标志物）。年龄增长、空腹血糖升高、基底节血管周围间隙>10个增大和非腔隙性卒中与颈动脉虹吸中的高钙含量有关。相比之下，男性、中度至重度白质高信号、腔隙性和非腔隙性卒中与颅内动脉显著狭窄相关。有任何ICAD生物标志物的受试者比没有ICAD生物标志物的受试者更容易发生中风（29%对9%，p<0.001）。与颈动脉虹吸中的高钙含量相比，颅内动脉显著狭窄更容易与中风相关，这表明CSC更可能是ICAD生物标记物，而不是与中风的因果关系。结论：美洲印第安人ICAD患病率较高，且与中风显著相关。CSC和颅内动脉明显狭窄可能代表ICAD的不同表型。（c） 2020爱思唯尔公司版权所有。

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