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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality
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Serum Levels of B-cell Lymphoma-2 Anti-Apoptotic Protein and Malignant Middle Cerebral Artery Infarction Mortality

机译：B细胞淋巴瘤-2抗凋亡蛋白和恶性中脑动脉梗死死亡率的血清水平

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Introduction and Goal: There is scarce and contradictory data on B-cell lymphoma 2 (Bcl2), member of the Bcl-2 antiapoptotic molecules family of intrinsic apoptosis pathway, in ischemic stroke patients. The objective of this study was to determine whether there is an association between blood Bcl2 concentrations and mortality of ischemic stroke patients. Material and Methods: Five Intensive Care Units partici-pated in this prospective and observational study of patients with severe malignant middle cerebral artery infarction (MMCAI). Severe MMCAI was diagnosed when acute infarction was present in 50% or more of said region and with a Glasgow Coma Scale (GCS) score of less than 9 points. Serum samples were collected at the time of MMCAI diagnosis. Findings: Higher serum Bcl2 concentrations (p = 0.001), lower platelet count (p = 0.01) and lower GCS (p = 0.002) were found in non-survi-vors (n = 28) than in MMCAI survivors (n = 28). Serum Bcl2 levels had an area under the curve for mortality prediction of 75% (95% CI = 62%-88%; p 43.6 ng/mL had higher mortality rate according to Kaplan-Meier analysis (Hazard ratio=10.0; 95% CI = 3.4-29.5; p < 0.001). Multi-ple logistic regression showed an association between serum Bcl2 and mortality at 30 days (OR = 1.041; 95% CI = 1.006-1.077; p = 0.02) controlling for GCS and plate -let count. Conclusions: This study reports for the first time the higher blood Bcl2 con-centrations in non-surviving ischemic stroke patients than in survivors and the association between elevated blood Bcl2 and mortality in ischemic stroke patients.
机译：导言和目的：关于缺血性中风患者中的Bcl-2抗凋亡分子家族成员B细胞淋巴瘤2（Bcl2）的数据很少且相互矛盾。本研究的目的是确定血液Bcl2浓度与缺血性中风患者死亡率之间是否存在相关性。材料和方法：五个重症监护病房参与了对严重恶性大脑中动脉梗死（MMCAI）患者的前瞻性观察研究。当上述区域50%或以上出现急性梗死且格拉斯哥昏迷评分（GCS）低于9分时，诊断为严重MMCAI。在MMCAI诊断时收集血清样本。结果：与MMCAI幸存者（n=28）相比，非存活VOR患者（n=28）的血清Bcl2浓度较高（p=0.001）、血小板计数较低（p=0.01）和GCS较低（p=0.002）。根据Kaplan-Meier分析，血清Bcl2水平的死亡率预测曲线下面积为75%（95%CI=62%-88%；p43.6 ng/mL具有更高的死亡率（危险比=10.0；95%CI=3.4-29.5；p<0.001）。多重logistic回归显示血清Bcl2与控制GCS和平板计数的30天死亡率（OR=1.041；95%CI=1.006-1.077；p=0.02）之间存在相关性。结论：本研究首次报道了非存活缺血性卒中患者的血Bcl2浓度高于存活缺血性卒中患者，以及血Bcl2升高与缺血性卒中患者死亡率之间的关系。

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