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首页> 外文期刊>Annual Review of Statistics and Its Application >Modern Statistical Challenges in High-Resolution Fluorescence Microscopy
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Modern Statistical Challenges in High-Resolution Fluorescence Microscopy

机译：高分辨率荧光显微镜的现代统计挑战

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Conventional light microscopes have been used for centuries for the study of small length scales down to approximately 250 nm. Images from such a microscope are typically blurred and noisy, and the measurement error in such images can often be well approximated by Gaussian or Poisson noise. In the past, this approximation has been the focus of a multitude of deconvolution techniques in imaging. However, conventional microscopes have an intrinsic physical limit of resolution. Although this limit remained unchallenged for a century, it was broken for the first time in the 1990s with the advent of modern superresolution fluorescence microscopy techniques. Since then, superresolution fluorescence microscopy has become an indispensable tool for studyingthe structure and dynamics of living organisms. Current experimental advances go to the physical limits of imaging, where discrete quantum effects are predominant. Consequently, this technique
机译：数百年来，传统的光学显微镜已被用于研究小至250 nm左右的小尺寸鳞片。来自这种显微镜的图像通常模糊且嘈杂，并且此类图像中的测量误差通常可以由高斯或泊松噪声很好地近似。过去，这种近似一直是成像中多种反卷积技术的重点。然而，常规显微镜具有分辨率的固有物理极限。尽管这个极限在一个世纪内一直没有受到挑战，但随着现代超分辨率荧光显微镜技术的出现，它在1990年代首次被打破。从那时起，超分辨率荧光显微镜已成为研究活生物体的结构和动力学的必不可少的工具。当前的实验进展达到了成像的物理极限，其中离散量子效应占主导。因此，这种技术

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