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首页> 外文期刊>Journal of tissue engineering and regenerative medicine >Fibrin, the preferred scaffold for cell transplantation after myocardial infarction? An old molecule with a new life
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Fibrin, the preferred scaffold for cell transplantation after myocardial infarction? An old molecule with a new life

机译：纤维蛋白，心肌梗死后细胞移植的首选支架吗？ 一个新的生活的旧分子

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摘要

Fibrin is a topical haemostat, sealant and tissue glue, which consists of concentrated fibrinogen and thrombin. It has broad medical and research uses. Recently, several studies have shown that engineered patches comprising mixtures of biological or synthetic materials and progenitor cells showed therapeutic promise for regenerating damaged tissues. In that context, fibrin maintains cell adherence at the site of injury, where cells are required for tissue repair, and offers a nurturing environment that protects implanted cells without interfering with their expected benefit. Here we review the past, present and future uses of fibrin, with a focus on its use as a scaffold material for cardiac repair. Fibrin patches filled with regenerative cells can be placed over the scarring myocardium; this methodology avoids many of the drawbacks of conventional cell-infusion systems. Advantages of using fibrin also include extraction from the patient's blood, an easy readjustment and implantation procedure, increase in viability and early proliferation of delivered cells, and benefits even with the patch alone. In line with this, we discuss the numerous preclinical studies that have used fibrin-cell patches, the practical issues inherent in their generation, and the necessary process of scaling-up from animal models to patients. In the light of the data presented, fibrin stands out as a valuable biomaterial for delivering cells to damaged tissue and for promoting beneficial effects. However, before the fibrin scaffold can be translated from bench to bedside, many issues must be explored further, including suboptimal survival and limited migration of the implanted cells to underlying ischaemic myocardium. Copyright (c) 2016 John Wiley & Sons, Ltd.
机译：纤维蛋白是一种局部止血剂、密封剂和组织胶，由浓缩纤维蛋白原和凝血酶组成。它有广泛的医学和研究用途。最近，几项研究表明，由生物或合成材料和祖细胞的混合物组成的工程化贴片显示出再生受损组织的治疗前景。在这种情况下，纤维蛋白在损伤部位（组织修复所需的细胞）维持细胞粘附，并提供一个滋养环境，保护植入细胞而不影响其预期益处。在这里，我们回顾了纤维蛋白的过去、现在和未来的用途，重点介绍了它作为心脏修复支架材料的用途。充满再生细胞的纤维蛋白贴片可以放置在疤痕累累的心肌上；这种方法避免了传统细胞输注系统的许多缺点。使用纤维蛋白的优点还包括从患者血液中提取、易于重新调整和植入程序、提高所输送细胞的存活率和早期增殖，甚至单独使用贴片也有好处。根据这一点，我们讨论了大量使用纤维蛋白细胞贴片的临床前研究，它们产生过程中固有的实际问题，以及从动物模型扩展到患者的必要过程。根据所提供的数据，纤维蛋白是一种有价值的生物材料，用于将细胞输送到受损组织，并促进有益效果。然而，在将纤维蛋白支架从工作台转移到床边之前，必须进一步探讨许多问题，包括植入细胞的亚最佳存活率和向潜在缺血心肌的有限迁移。版权所有（c）2016约翰威利父子有限公司。

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