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首页> 外文期刊>Annals of Tropical Paediatrics >Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda.
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Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda.

机译：在欧洲和乌干达，未接触HIV的未感染HIV的儿童的淋巴细胞，CD4 +，CD8 +和中性粒细胞水平的种族差异之内和之间。

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BACKGROUND: Racial immuno-haematological differences have been reported in children but to date have not been well quantified. AIM: To investigate differences in haemato-immunological markers over age between children born and living in Europe and Uganda. SUBJECTS: HIV-uninfected children living in Uganda (n = 1633) with cross-sectional data. Black (n = 604) and white children (n = 1355) living in Europe, both with prospective data. The children born in Europe were HIV-uninfected but born to HIV-infected mothers and were included in the European Collaborative Study (ECS). METHODS: Patterns and levels of total lymphocyte (TLC), CD4+, CD8+ counts and CD4% were visualised by smoothers (a line representing the weighted average of all measurements over age by study group). Differences between groups were quantified using age-standardised Z-scores for individual TLC, CD4+ and CD8+ counts in uni- and multivariate regression models. RESULTS: In infancy, TLC, CD4+ and CD8+ counts were lower in Ugandan than black European children; neutrophil counts were similar. Thereafter, only neutrophil counts were lower in Ugandan children. To assess within-race differences, we compared Z-scores of ECS children born to Ugandan mothers with those of Ugandan children. Levels of all four markers were lower in Ugandan children at all ages. In Ugandan children, CD4+ counts were 0.5985 Z-score (p < 0.001) and neutrophil counts 0.3872 Z-score (p < 0.001) lower than in European children born to Ugandan mothers. CONCLUSIONS: There are differences in levels of haemato-immunological markers in children with comparable genetic backgrounds, suggesting that environmental factors such as nutrition and exposure to micro-organisms might have important effects on the developing immune system.
机译：背景：已经报道了儿童的种族免疫血液学差异，但迄今为止尚未得到很好的量化。目的：调查在欧洲和乌干达出生和生活的儿童之间在年龄上血液免疫标记物的差异。研究对象：居住在乌干达的未感染艾滋病毒的儿童（n = 1633），并提供横断面数据。居住在欧洲的黑人（n = 604）和白人孩子（n = 1355）都有前瞻性数据。在欧洲出生的孩子没有受到HIV感染，但由感染HIV的母亲所生，被纳入欧洲合作研究（ECS）。方法：通过平滑器显示总淋巴细胞（TLC），CD4 +，CD8 +计数和CD4％的模式和水平（一条线代表研究组所有年龄段所有测量值的加权平均值）。使用年龄标准化的Z评分对单因素和多元回归模型中的个体TLC，CD4 +和CD8 +计数量化组之间的差异。结果：在婴儿期，乌干达的TLC，CD4 +和CD8 +计数低于欧洲黑人儿童。中性粒细胞计数相似。此后，乌干达儿童中只有中性粒细胞计数较低。为了评估种族差异，我们比较了乌干达母亲和乌干达儿童的ECS儿童的Z得分。在所有年龄段的乌干达儿童中，所有四个标记物的水平均较低。在乌干达儿童中，CD4 +计数为0.5985 Z分数（p <0.001），而中性粒细胞计数为0.3872 Z分数（p <0.001），低于在欧洲由乌干达母亲所生的儿童。结论：具有相似遗传背景的儿童的血液免疫标记物水平存在差异，这表明诸如营养和暴露于微生物等环境因素可能对发育中的免疫系统产生重要影响。

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