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首页> 外文期刊>Annual Review of Analytical Chemistry >Cell-Based Microarrays for In Vitro Toxicology
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Cell-Based Microarrays for In Vitro Toxicology

机译：基于细胞的体外毒理学微阵列

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摘要

DNA/RNA and protein microarrays have proven their outstanding bioanalytical performance throughout the past decades, given the unprecedented level of parallelization by which molecular recognition assays can be performed and analyzed. Cell microarrays (CMAs) make use of similar construction principles. They are applied to profile a given cell population with respect to the expression of specific molecular markers and also to measure functional cell responses to drugs and chemicals. This review focuses on the use of cell-based microarrays for assessing the cytotoxicity of drugs, toxins, or chemicals in general. It also summarizes CMA construction principles with respect to the cell types that are used for such microarrays, the readout parameters to assess toxicity, and the various formats that have been established and applied. The review ends with a critical comparison of CMAs and well-established microtiter plate (MTP) approaches.
机译：DNA / RNA和蛋白质微阵列在过去几十年中证明了其出色的生物分析性能，这是因为可以进行分子识别测定和分析的平行化水平达到了前所未有的水平。细胞微阵列（CMA）利用相似的构造原理。它们可用于根据特定分子标记的表达来分析给定的细胞群，还可以测量细胞对药物和化学物质的反应。这篇综述主要集中在基于细胞的微阵列在评估药物，毒素或化学物质的细胞毒性方面的用途。它还概述了有关此类微阵列所用细胞类型，评估毒性的读出参数以及已建立和应用的各种格式的CMA构建原理。审查以对CMA和公认的微量滴定板（MTP）方法的关键比较结束。

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