Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells

Nickel W; Seedorf M

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Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells

机译：蛋白质转运到真核细胞表面的非常规机制

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The classical secretion of soluble proteins and transport of integral membrane proteins to the cell surface require transit into and through the endoplasmic reticulum and the Golgi apparatus. Signal peptides or transmembrane domains target proteins for translocation into the lumen or insertion into the membrane of the endoplasmic reticulum, respectively. Here we discuss two mechanisms of unconventional protein targeting to plasma membranes, i.e., transport processes that are active in the absence of a functional Golgi system. We first focus on integral membrane proteins that are inserted into the endoplasmic reticulum but that, however, are transported to plasma membranes in a Golgi-independent manner. We then discuss soluble secretory proteins that are secreted from cells without any involvement of the endoplasmic reticulum and the Golgi apparatus.

机译：可溶性蛋白的经典分泌和整合膜蛋白向细胞表面的转运需要转运进入并穿过内质网和高尔基体。信号肽或跨膜结构域靶向蛋白质，分别转运至内腔或插入内质网的膜中。在这里，我们讨论了非常规蛋白质靶向质膜的两种机制，即在没有功能性高尔基体系统的情况下活跃的转运过程。我们首先关注插入到内质网中的完整膜蛋白，但是这些蛋白以高尔基体独立的方式转运到质膜。然后，我们讨论了细胞分泌的可溶性分泌蛋白，而没有任何内质网和高尔基体的参与。

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《Annual review of cell and developmental biology》 |2008年第0期|共22页
作者
Nickel W; Seedorf M;
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正文语种 eng
中图分类细胞生物学;
关键词
Animals; Cell Membrane metabolism ultrastructure; Endoplasmic Reticulum metabolism; Eukaryotic Cells cytology metabolism; Fibroblast Growth Factor 2 secretion; Golgi Apparatus metabolism; Models; Biological; Protein Transport physiology;

机译：动物;细胞膜代谢超微结构;内质网代谢;真核细胞细胞学代谢;成纤维细胞生长因子2分泌;高尔基体代谢;模型;生物学;蛋白质转运生理学;

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1. Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells [J] . Nickel W, Seedorf M Annual review of cell and developmental biology . 2008,第0期

机译：蛋白质转运到真核细胞表面的非常规机制
2. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. [J] . Samuvel DJ, Jayanthi LD, Bhat NR, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2005,第1期

机译：p38丝裂原活化蛋白激酶在5-羟色胺转运蛋白调控中的作用：转运蛋白表面表达所涉及的不同细胞机制的证据。
3. The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms [J] . NatarajanK., BhullarJ., ShuklaS., Biochemical Pharmacology . 2013,第4期

机译：Pim激酶抑制剂SGI-1776通过Pim-1依赖性和非依赖性机制降低P-糖蛋白（ABCB1）和乳腺癌抗性蛋白（ABCG2）的细胞表面表达以及药物转运
4. High speed tracking of protein bodies: revealing the transport mechanisms in living plant cells [C] . C. Lopez-Quesada, M. Joseph, M. D. Ludevid, European Optical Society annual meeting;EOSAM 2010 . 2010

机译：蛋白质体的高速跟踪：揭示活植物细胞中的转运机制
5. The mechanism of heme transfer from the streptococcal cell surface protein Shp to HtsA of the HtsAbc transporter. [D] . Ran, Yanchao. 2010

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6. A Role for p38 Mitogen-Activated Protein Kinase in the Regulation of the Serotonin Transporter: Evidence for Distinct Cellular Mechanisms Involved in Transporter Surface Expression [O] . Devadoss J. Samuvel, Lankupalle D. Jayanthi, Narayan R. Bhat, 2005

机译：p38丝裂原激活的蛋白激酶在5-羟色胺转运蛋白调控中的作用：涉及转运蛋白表面表达的不同细胞机制的证据。
7. Plantaricin A, a cationic peptide produced by Lactobacillus plantarum, permeabilizes eukaryotic cell membranes by a mechanism dependent on negative surface charge linked to glycosylated membrane proteins [O] . Sand Sverre L., Nissen-Meyer Jon, Sand Olav, 2013

机译：植物乳杆菌A，一种由植物乳杆菌产生的阳离子肽，通过依赖于与糖基化膜蛋白相连的负表面电荷的机理使真核细胞膜通透。
8. Senescence Marker Protein 30 (SMP30) Expression in Eukaryotic Cells: Existence Of Multiple Species and Membrane Localization [R] . Arun, P., Aleti, V., Parikh, K., 2011

机译：衰老标记蛋白30（smp30）在真核细胞中的表达：多种类的存在和膜定位

Unconventional mechanisms of protein transport to the cell surface of eukaryotic cells

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