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首页> 外文期刊>Annual review of cell and developmental biology >Tethering factors as organizers of intracellular vesicular traffic. [Review]
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Tethering factors as organizers of intracellular vesicular traffic. [Review]

机译:栓系因子是细胞内水泡运输的组织者。 [评论]

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摘要

Intracellular trafficking entails the budding, transport, tethering, and fusion of transport vesicles and other membrane carriers. Here we review recent progress toward a mechanistic understanding of vesicle tethering. The known tethering factors are large complexes important for one or more intracellular trafficking pathways and are capable of interacting directly with many of the other principal components of the cellular trafficking machinery. Our review emphasizes recent developments in the in vitro reconstitution of vesicle tethering and the structural characterization of multisubunit tethering factors. The combination of these and other approaches has led to exciting progress toward understanding how these essential nanomachines work.
机译:细胞内运输需要运输囊泡和其他膜载体的出芽,运输,束缚和融合。在这里,我们回顾了对囊泡束缚的机械理解的最新进展。已知的束缚因子是对于一个或多个细胞内运输途径重要的大复合物,并且能够直接与细胞运输机制的许多其他主要成分相互作用。我们的审查强调了囊泡束缚的体外重建和多亚基束缚因子的结构表征的最新进展。这些方法和其他方法的结合已导致在理解这些基本的纳米机器如何工作方面取得了令人兴奋的进步。

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