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首页> 外文期刊>Annals of epidemiology >Alcohol Consumption and Mortality among Middle-aged and Elderly Japanese Men and Women.
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Alcohol Consumption and Mortality among Middle-aged and Elderly Japanese Men and Women.

机译：日本中老年男女的饮酒量和死亡率。

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PURPOSE: We conducted a prospective cohort study to examine the association between alcohol intake and the risk of all-cause mortality among middle-aged and elderly Japanese men and women. METHODS: At baseline (1988-1990), a total of 110,792 Japanese men and women aged 40 to 79 years were asked to complete a questionnaire that included information on alcohol intake, and were followed up for all-cause mortality through December 31, 1999. Relative risks (95% confidence interval) were calculated using Cox proportional-hazards models. RESULTS: The risk of all-cause mortality was lowest among current drinkers with an alcohol intake of 0.1 to 22.9 g/d (RR, 0.80; 95% CI, 0.72-0.88 for men; and RR, 0.88; 95% CI, 0.77-1.00 for women). Excessive mortality associated with heavy drinking (>/= 69 g/d) was observed for cancer, cardiovascular disease and injuries and other external causes in men, while significantly reduced mortality with light drinking was seen for cancer in men and CVD in women. For men, the benefit associated with light alcohol consumption (< 23 g/d) was more apparent among nonsmokers than among smokers. CONCLUSION: Our prospective data show a 12% to 20% decreased risk of all-cause mortality in both Japanese men and women who consumed less than 23 g/d of alcohol (approximately 2 drinks), although heavy drinking increased that risk.
机译：目的：我们进行了一项前瞻性队列研究，以研究饮酒与日本中老年男性和女性的全因死亡率风险之间的关系。方法：在基线（1988-1990年），总共110,792名40-79岁的日本男性和女性被要求填写一份包括酒精摄入信息的问卷，并随访至1999年12月31日的全因死亡率使用Cox比例风险模型计算相对风险（95％置信区间）。结果：在目前饮酒量为0.1至22.9 g / d的饮酒者中，全因死亡率的风险最低（男性，RR，0.80; 95％CI，0.72-0.88; RR，0.88; 95％CI，0.77 -1.00（女性）。在男性中，癌症，心血管疾病和损伤以及其他外部原因导致了与大量饮酒相关的过度死亡率（> / = 69 g / d），而男性癌症和女性的CVD则导致饮酒显着降低死亡率。对于男性，与不吸烟者相比，不吸烟者与轻度饮酒（<23 g / d）相关的益处更为明显。结论：我们的前瞻性数据显示，每天饮酒少于23 g / d（约2杯）的日本男性和女性的全因死亡率降低了12％至20％，尽管大量饮酒会增加这种风险。

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