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首页> 外文期刊>Annals of epidemiology >Body mass index and breast cancer risk in African American women.
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Body mass index and breast cancer risk in African American women.

机译：非洲裔美国妇女的体重指数和乳腺癌风险。

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PURPOSE: Studies of the relationship between body mass index (BMI) and breast cancer in African American women have been few. We conducted a case-control study to examine whether BMI is associated with risk of breast cancer in this population. METHODS: Cases were 304 women diagnosed with breast cancer at the ages of 20 to 64 years. Controls were 305 women without a history of breast cancer. Telephone interviews were conducted to collect data on history of exposure to various factors at or before the date of diagnosis in cases or equivalent date in controls (reference date). Using logistic regression, we compared cases and controls in BMI at age 18, BMI at the reference date, and change in BMI between the two dates. RESULTS: Using BMI at reference date, we found an odds ratio (OR) of 1.75 (95% confidence interval [CI], 1.02-3.02) and 2.32 (95% CI, 1.33-4.03) for women with BMI of 25 to 29.9 and 30 or higher, respectively, compared with women having BMI lower than 25. The corresponding OR estimates for BMI at age 18 were not significantly different from the unity. The average annual change in BMI between age 18 and date of diagnosis or reference date was associated with breast cancer risk, as shown that more BMI change tended to increase breast cancer risk compared with the baseline quartile of change. When data were analyzed by menopausal status, the association was found for both post-menopausal and pre-menopausal tumors for BMI at reference date but not for BMI at age 18. There was a higher risk for more annual BMI change compared with the baseline for both pre-menopausal and post-menopausal women. CONCLUSION: Our results suggest that BMI at reference date and change in BMI were associated with increased risk of breast cancer in African American women, and the association might be found for both post-menopausal and pre-menopausal tumors.
机译：目的：对非洲裔美国女性的体重指数（BMI）与乳腺癌之间关系的研究很少。我们进行了一项病例对照研究，以检查该人群中BMI是否与患乳腺癌的风险有关。方法：病例为304名20至64岁被诊断出患有乳腺癌的女性。对照组为305名无乳腺癌史的妇女。进行电话访问以收集有关病例诊断日期或之前或对照中的等效日期（参考日期）的各种因素暴露史的数据。使用逻辑回归分析，我们比较了18岁时BMI，参考日BMI和两个日期之间BMI的变化的病例和对照。结果：在参考日期使用BMI，我们发现BMI为25至29.9的女性的比值比（OR）为1.75（95％置信区间[CI]，1.02-3.02）和2.32（95％CI，1.33-4.03）。与BMI低于25的女性相比，分别为30％和30％或更高。18岁时BMI的相应OR估计值与统一没有显着差异。在18岁至诊断日期或参考日期之间，BMI的年平均变化与乳腺癌风险有关，这表明与基线四分位数变化相比，更多的BMI变化往往会增加乳腺癌风险。当按更年期状态分析数据时，发现在参考日期BMI绝经后和绝经前肿瘤的相关性，但在18岁时未见BMI的相关性。与基线相比，发生更多BMI年度变化的风险更高绝经前和绝经后妇女。结论：我们的结果表明，参考日期的BMI和BMI的变化与非裔美国女性患乳腺癌的风险增加有关，而且绝经后和绝经前肿瘤均可能存在这种关联。

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