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首页> 外文期刊>Annals of epidemiology >Alcohol consumption and risk of hematologic malignancies.
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Alcohol consumption and risk of hematologic malignancies.

机译：饮酒和血液系统恶性肿瘤的风险。

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PURPOSE: Limited data suggest that alcohol drinking may have an inverse relation to risk of non-Hodgkin's lymphoma (NHL). Prospective data about alcohol, NHL, and other hematologic malignancies (HM) are sparse. METHODS: We carried out a cohort study in a multiethnic population of 126,293 adults who supplied baseline information at health examinations. There were subsequent HM diagnoses in 1244 persons. We used Cox proportional hazards models with seven covariates. The role of beverage types was studied by comparing groups with preponderant choices and by studying the role of frequency of drinking beverage types. RESULTS: Using lifelong abstainers plus infrequent drinkers as referent, adjusted relative risks (95% confidence intervals) for HM follow: less than one drink per day=1.0 (0.9-1.2), one to two drinks per day=0.9 (0.7-1.0), greater than three drinks per day=0.7 (0.6-0.9, p=0.008). For 673 NHL these were 1.2 (1.0-1.5), 0.9 (0.7-1.2), and 0.9 (0.6-1.2). Persons reporting greater than three drinks/day had inverse relations to lymphocytic (n= 146) and myelocytic (n= 169) leukemias, with relative risk of 0.5 (0.2-1.0, p<0.05) for each. No major independent relation was seen for choice of wine, liquor, or beer. CONCLUSIONS: Alcohol drinking is associated with slightly lower risk of HM, due largely to inverse relations to lymphocytic and myelocytic leukemia.
机译：目的：有限的数据表明，饮酒可能与非霍奇金淋巴瘤（NHL）的风险成反比。关于酒精，NHL和其他血液系统恶性肿瘤（HM）的前瞻性数据很少。方法：我们在126,293名成年人的多民族人群中进行了一项队列研究，他们在健康检查中提供了基线信息。随后有124例HM诊断。我们使用具有七个协变量的Cox比例风险模型。通过将群体与主要选择进行比较，并研究饮用饮料类型的频率的作用，研究了饮料类型的作用。结果：以终身戒酒者和不常饮酒的人为参考，调整后的HM相对危险度（95％置信区间）如下：每天少于一次喝酒= 1.0（0.9-1.2），每天少于一到两次喝酒= 0.9（0.7-1.0 ），则每天多于三杯饮料= 0.7（0.6-0.9，p = 0.008）。对于673个NHL，分别为1.2（1.0-1.5），0.9（0.7-1.2）和0.9（0.6-1.2）。每天喝三杯以上酒的人与淋巴细胞性白血病（n = 146）和粒细胞性白血病（n = 169）呈反比关系，每项的相对风险为0.5（0.2-1.0，p <0.05）。对于葡萄酒，白酒或啤酒的选择，没有发现主要的独立关系。结论：饮酒与HM的患病风险略低有关，这在很大程度上是由于与淋巴细胞白血病和粒细胞白血病呈反比关系。

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