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首页> 外文期刊>Annals of epidemiology >Birth weight of offspring, maternal pre-pregnancy characteristics, and mortality of mothers: the Jerusalem perinatal study cohort.
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Birth weight of offspring, maternal pre-pregnancy characteristics, and mortality of mothers: the Jerusalem perinatal study cohort.

机译：耶路撒冷围产期研究队列：后代的出生体重，母亲的孕前特征和母亲的死亡率。

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PURPOSE: To explore the association between birth weight in offspring, a marker of the intrauterine environment, and mortality in their mothers, taking into account maternal pre-pregnancy characteristics, including maternal body mass index (BMI), smoking, and socioeconomic status. Distinguishing the effects of offspring's birth weight and pre-pregnancy characteristics on maternal outcome may provide clues regarding mechanisms underlying the association between birth weight and maternal mortality. METHODS: We studied long-term total mortality (average follow-up period, 29.1 years) in a population-based cohort of 13,185 mothers, aged 15 to 48 years at their offspring's birth, who delivered in West Jerusalem during 1974 through 1976. RESULTS: Univariate and multivariate Cox-proportional hazard models used to estimate the hazard of overall mortality among mothers indicated a nonlinear relationship with birth weight of offspring when introduced into the models as a continuous variable, and a linear positiveassociation with maternal pre-pregnancy BMI. Inclusion of maternal BMI and other pre-pregnancy characteristics in the model did not alter the association between offspring's birth weight and mothers' all-cause mortality. When birth weight was introduced as a categorical variable, higher mortality was observed among mothers who gave birth to babies with birth weight less than 2500 g (hazard ratio [HR] = 1.90; 95% confidence interval [95%CI], 1.23-2.94) as compared to mothers whose offspring had birth weight between 3000 and 3499 g. The HR for mothers who gave birth to babies with birth weight 4000 g or more was 1.30 (95%CI, 0.88-1.91). CONCLUSIONS: Independent of pre-pregnancy maternal BMI and other characteristics, birth weight of offspring was associated with mortality in their mothers, suggesting that intrauterine metabolic events reflected by birth weight and not explained by maternal obesity, smoking, and socioeconomic status have remote consequences for maternal health. These findings underline the need to explore specific genetic and/or environmental mechanisms that account for these associations.
机译：目的：探讨母体的孕前特征，包括母体质量指数（BMI），吸烟和社会经济状况，以探讨子代出生体重（宫内环境的标志）与母亲死亡率之间的关系。区分后代的出生体重和孕前特征对孕产妇结局的影响，可能提供有关出生体重和孕产妇死亡率之间关联机制的线索。方法：我们研究了1974年至1976年在西耶路撒冷分娩的13185名母亲，其后代年龄在15至48岁之间，以人群为基础的队列中的长期总死亡率（平均随访期为29.1年）。 ：用于估计母亲整体死亡率危险的单变量和多变量Cox比例风险模型表明，当将其作为连续变量引入模型时，该变量与后代的出生体重呈非线性关系，而与孕前BMI呈线性正相关。在模型中纳入母亲的BMI和其他孕前特征并未改变后代的出生体重与母亲的全因死亡率之间的关联。当引入出生体重作为分类变量时，出生体重小于2500 g的婴儿的母亲死亡率更高（危险比[HR] = 1.90; 95％置信区间[95％CI]，1.23-2.94 ），而后代的出生体重在3000至3499克之间的母亲。出生体重在4000 g或以上的婴儿的母亲的HR为1.30（95％CI，0.88-1.91）。结论：独立于孕前母亲的BMI和其他特征，后代的出生体重与母亲的死亡率有关，这表明宫内代谢事件由出生体重反映，而不是由母亲的肥胖，吸烟和社会经济状况所解释，这对产妇保健。这些发现强调了需要探索导致这些关联的特定遗传和/或环境机制。

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