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首页> 外文期刊>Annals of epidemiology >Differential Impact of Risk Factors for Women and Men on the Risk of Major Depressive Disorder
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Differential Impact of Risk Factors for Women and Men on the Risk of Major Depressive Disorder

机译：男女危险因素对重度抑郁症风险的差异影响

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Purpose: Our aim is to examine which risk factors have a greater impact in women than in men on the risk of major depressive disorder (MDD) and whether factors differ between a possible recurrent MDD and a first onset of MDD. Methods: Prospective cohort study of general practice attendees in seven countries, who were followed up at 6 and 12 months (predictD). Absolute risk differences (interaction contrast) across sex for onset of DSM-IV MDD after 6 or 12 months of follow-up were estimated for 35 risk factors from 7101 participants without MDD at baseline. Results: A total of 599 participants (80% female) had an onset of MDD at 6 or 12 months. Most risk factors had a greater impact in women than in men on the risk of MDD and were not restricted to a specific class of risk factors. After we stratified for a history of depressive symptoms, we found that the impact of risk factors across sex was generally stronger on possible recurrent MDD than on a first onset of MDD. Conclusions: Our findings may partly account for the observed difference in incidence of MDD between men and women.
机译：目的：我们的目的是研究哪些风险因素对女性的抑郁比男性对男性的影响更大，以及在可能的复发性MDD和首次MDD发作之间因素是否有所不同。方法：前瞻性队列研究了七个国家的全科医师，分别在6和12个月时进行了随访（预测）。随访6或12个月后，DSM-IV MDD发作的性别之间的绝对风险差异（交互作用对比）被估计为来自基线时没有MDD的7101名参与者的35个危险因素。结果：共有599名参与者（80％为女性）在6或12个月时患有MDD。与男性相比，大多数危险因素对女性的影响比对男性的影响更大，并且不限于特定类别的危险因素。在对抑郁症状的历史进行分层后，我们发现，跨性别的危险因素对可能复发的MDD的影响通常要强于首次出现MDD的影响。结论：我们的发现可能部分解释了男女之间MDD发生率的差异。

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