首页> 外文期刊>Cyclodextrin news >Cholesterol-binding Cyclodextins for the Treatment of Cystic Fibrosis and Other Diseases with Pulmonary Surfactant Dysfunction
【24h】

Cholesterol-binding Cyclodextins for the Treatment of Cystic Fibrosis and Other Diseases with Pulmonary Surfactant Dysfunction

机译:用于治疗囊性纤维化和其他肺表面活性剂功能障碍的胆固醇结合环境蛋白原

获取原文
获取原文并翻译 | 示例
           

摘要

Cystic Fibrosis (CF) is a life-threatening genetic disorder where thick mucus is built up in the lungs, causing severe respiratory problems and complications (such as bacterial infection and inflammation). Pulmonary surfactant (PS) is a surface active substance lining the respiratory system of mammalian lung secreted by type-II alveolar epithelial cells [1]. It is a thin lipid-protein film at the air-liquid interface in the lungs. Its function is to dynamically control the surface tension of the boundary surface during the breathing cycle. The surface tension of water is about 70 mN/m, but in the lungs only about 25 mN/m, which is further decreased to near 0 mN/m when the PS film becomes compressed at the end of expiration. This low surface tension controlled by PS decreases the pressure difference between inflation and deflation of lung and as a consequence reduces the work of breathing and prevent alveolar collapse at low lung volumes. The surface forces help also to get rid of the inhaled particles. PS dysfunction results in impaired ability of lung to expand, in decreased lung volume, reduced airway patency and hypoxia.
机译:囊性纤维化(CF)是一种威胁生命的遗传疾病,在肺部内建立浓稠的粘液,导致严重的呼吸道问题和并发症(例如细菌感染和炎症)。肺表面活性剂(PS)是一种表面活性物质,内衬由II型肺泡上皮细胞分泌的哺乳动物肺的呼吸系统[1]。它是肺部空气界面处的薄脂质蛋白膜。它的功能是在呼吸周期中动态控制边界表面的表面张力。水的表面张力约为70 mn/m,但在肺中仅约25 mn/m,当PS膜在到期结束时被压缩时,该肺部进一步降低至接近0 mn/m。由PS控制的这种低表面张力减少了肺通货膨胀和通气之间的压力差,因此减少了呼吸的工作,并防止在低肺体积下肺泡塌陷。表面力也有助于摆脱吸入的颗粒。 PS功能障碍导致肺部膨胀能力减少,气道通畅和缺氧的能力受损。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号