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首页> 外文期刊>Annals of epidemiology >Cardiovascular risk among men seeking help for erectile dysfunction.
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Cardiovascular risk among men seeking help for erectile dysfunction.

机译：寻求勃起功能障碍帮助的男性中的心血管风险。

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PURPOSE: The introduction of sildenafil put the risk of cardiovascular disease (CVD) among men with erectile dysfunction (ED) on the agenda of physicians. The question arose, Is EDsentinel to CVD? We sought to answer this question in the present study. METHODS: A historical cohort study was set up using medical records of general practices all over the Netherlands. Incident cases of ED were selected before and after the introduction of sildenafil using a catchment population of 60,000 men aged 35 to 74 years. Two to three men without ED (controls) were, subsequently, matched to each case. Incidence of CVD was determined for cases and controls, respectively. RESULTS: Overall, incidence of ED doubled from 5.3 per 1000 men-years in the period before introduction of sildenafil to 10.1 after the introduction. The relative risk of incident CVD among men with ED compared to controls was 1.7 [95%-CI 0.9-3.3] before the introduction and 1.1 [95%-CI 0.6-1.8] afterwards. CONCLUSIONS: While ED could be seen as a marker for CVD before the introduction of sildenafil, it was clearly not afterwards.
机译：目的：西地那非的引入将勃起功能障碍（ED）男性的心血管疾病（CVD）风险列入医生议程。问题出现了，EDsentinel是否适用于CVD？我们试图在本研究中回答这个问题。方法：使用整个荷兰的常规医疗记录建立了一项历史队列研究。在引入西地那非之前和之后选择了ED的事件病例，使用了60,000名年龄在35至74岁之间的流域人口。随后，将两到三名没有ED的男性（对照组）与每个病例相匹配。分别确定病例和对照组的CVD发病率。结果：总体而言，ED的发生率从西地那非引入前的每1000人年5.3倍增加到引入后的10.1。与对照组相比，ED男性患CVD的相对风险为引入前的1.7 [95％-CI 0.9-3.3]，之后为1.1 [95％-CI 0.6-1.8]。结论：虽然ED在西地那非引入之前可以被认为是CVD的标志物，但显然在此之后没有。

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