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首页> 外文期刊>Annals of epidemiology >Birthweight of offspring and mortality of parents: the Jerusalem perinatal study cohort.
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Birthweight of offspring and mortality of parents: the Jerusalem perinatal study cohort.

机译：后代的出生体重和父母的死亡率：耶路撒冷围产期研究队列。

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PURPOSE: We sought to examine the association between birthweight in offspring and mortality in their parents. Distinguishing between risks of outcomes in mothers from fathers potentially provides clues as to the relative roles of genetic versus nongenetic mechanisms underlying these associations. METHODS: We studied total and cause-specific mortality in a population-based cohort of 37,718 mothers and 38,002 fathers whose offspring were delivered in West Jerusalem during 1964-1976, after an average follow-up of 34.12 years. RESULTS: Hazard models controlling for sociodemographic and lifestyle characteristics indicated a U-shaped relationship between offspring's birthweight and overall mortality, deaths from coronary heart disease, circulatory and other non-neoplastic causes in their mothers. Greater rates of mortality from coronary heart disease were observed among mothers who gave birth to babies with low (hazard ratio [HR], 2.13; 95% confidence interval [CI], 1.40-3.25) and high birthweight (HR, 1.98; 95% CI, 1.36-2.88), as compared with mothers whose offspring weighed 2500-3999 g at birth. Adjustment for maternal pre-eclampsia slightly attenuated these results. Multivariate models indicated a negative linear relationship (HR, 0.95; 95% CI, 0.91-0.99) between offspring's birthweight and overall mortality in their fathers. Unlike the association in mothers, the relation was noted primarily with deaths from "other causes." CONCLUSIONS: Birthweight of offspring is associated with parental mortality although the relation differs for fathers and mothers. These findings broaden previous observations that intra-uterine events have long-term consequences for adult health and support the need to explore genetic and/or environmental mechanisms underlying these associations.
机译：目的：我们试图研究后代出生体重与父母死亡率之间的关系。区分母亲与父亲的结局风险可能提供有关这些关联背后的遗传与非遗传机制的相对作用的线索。方法：在平均随访34.12年后，我们研究了1964年至1976年在西耶路撒冷分娩后代的37 718名母亲和38 002名父亲的人口基因和总死亡率。结果：控制社会人口统计学和生活方式特征的危害模型表明，后代的出生体重与总体死亡率，母亲的冠心病死亡，循环系统疾病和其他非肿瘤性原因之间呈U型关系。在出生率低（危险比[HR]，2.13; 95％置信区间[CI]，1.40-3.25）和高出生体重（HR，1.98; 95％）的母亲中，冠心病死亡率更高。 CI，1.36-2.88），而后代出生时体重为2500-3999 g的母亲则为。对孕妇先兆子痫的调整略微减弱了这些结果。多变量模型表明后代的出生体重与其父亲的总死亡率之间呈负线性关系（HR，0.95; 95％CI，0.91-0.99）。与母亲的交往不同，这种关系主要是由于“其他原因”造成的死亡。结论：后代的出生体重与父母的死亡率有关，尽管父亲和母亲之间的关系不同。这些发现扩大了以前的观点，即子宫内事件对成人健康具有长期影响，并支持探索这些关联基础的遗传和/或环境机制的需要。

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