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首页> 外文期刊>Annals of epidemiology >Low bone mineral density, coronary heart disease, and stroke mortality in men and women: the Third National Health and Nutrition Examination Survey.
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Low bone mineral density, coronary heart disease, and stroke mortality in men and women: the Third National Health and Nutrition Examination Survey.

机译：男女的低骨矿物质密度，冠心病和中风死亡率：第三次全国健康与营养调查。

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PURPOSE: The aim of this study is to determine the long-term association of bone mineral density and cardiovascular disease mortality. METHODS: The data used are from the Third National Health and Nutrition Examination Survey (NHANES III), a nationally representative sample of noninstitutionalized civilians. A cohort of white, black, and Mexican-American persons ages 50 years and older at baseline (1988-1994) was followed through 2000 for coronary heart disease (CHD; n = 4690) and stroke mortality (n = 5272) using the NHANES III Linked Mortality File. RESULTS: Death certificates were used to identify 369 CHD and 166 stroke deaths. Results were evaluated to determine the relative risk of CHD or stroke per one standard deviation lower bone mineral density after adjusting for multiple risk factors. In Cox proportional hazards models, risk of CHD death and risk of stroke death were not associated with low bone mineral density among men. For women, no significant associations were found for stroke (relativerisk, 1.34; 95% confidence interval, 0.86-2.07, p = 0.20) or CHD (relative risk, 1.26; 95% confidence interval, 0.88, 1.80; p = 0.21). CONCLUSIONS: Low bone mineral density was not associated with risk of cardiovascular disease in men. Among women with low bone mineral density, risk of CHD and stroke were elevated, but no significant associations were found.
机译：目的：本研究的目的是确定骨矿物质密度与心血管疾病死亡率的长期关联。方法：使用的数据来自第三次全国健康与营养检查调查（NHANES III），这是全国范围内非制度化平民的代表样本。基线时（1988-1994年），年龄为50岁及以上的白人，黑人和墨西哥裔美国人队列使用NHANES进行了2000年的冠心病（CHD; n = 4690）和中风死亡率（n = 5272）的随访。 III链接的死亡率文件。结果：死亡证明被用于识别369例CHD和166例中风死亡。在评估了多种危险因素后，评估结果以确定每降低一个标准偏差降低骨矿物质密度的冠心病或中风的相对风险。在Cox比例风险模型中，CHD死亡风险和中风死亡风险与男性低骨密度无关。对于女性，卒中（相对危险度为1.34; 95％置信区间为0.86-2.07，p = 0.20）或冠心病（相对危险度为1.26; 95％置信区间为0.88、1.80; p = 0.21）没有显着相关性。结论：低骨密度与男性患心血管疾病的风险无关。在骨矿物质密度低的女性中，冠心病和中风的风险升高，但未发现显着相关性。

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