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首页> 外文期刊>Annals of epidemiology >Reproductive windows, genetic loci, and breast cancer risk
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Reproductive windows, genetic loci, and breast cancer risk

机译：生殖窗，遗传位点和乳腺癌风险

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Purpose: The reproductive windows between age at menarche and age at first birth (standardized age at first birth) and from menarche to menopause (reproductive lifespan) may interact with genetic variants in association with breast cancer risk. Methods: We assessed this hypothesis in 6131 breast cancer cases and 7274 controls who participated in the population-based Collaborative Breast Cancer Study. Risk factor information was collected through telephone interviews, and DNA samples were collected on a subsample (N= 1484 cases, 1307 controls) to genotype for 13 genome-wide association study-identified loci. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and P values for the interaction between reproductive windows and genotypes were obtained by adding cross-product terms to statistical models. Results: For standardized age at first birth, the OR was 1.52 (CI, 1.36-1.71) comparing the highest quintile with the lowest quintile. Carrier status for rs10941679 (5p12) and rs10483813 (RAD51B) appeared to modify this relationship (P = .04 and P = .02, respectively). For reproductive lifespan, the OR comparing the highest quintile with the lowest quintiles was 1.62 (CI, 1.35-1.95). No interactions were detected between genotype and reproductive lifespan (all P > .05). All results were similar regardless of ductal versus lobular breast cancer subtype. Conclusions: Our results suggest that the reproductive windows are associated with breast cancer risk and that associations may vary by genetic variants.
机译：目的：初潮年龄与第一胎年龄（第一胎的标准年龄）之间以及从月经初潮到绝经（生殖寿命）之间的生殖窗可能与遗传变异相互作用，从而增加患乳腺癌的风险。方法：我们在参与基于人群的协作性乳腺癌研究的6131例乳腺癌病例和7274例对照中评估了这一假设。通过电话采访收集了危险因素信息，并在一个子样本（N = 1484例，1307个对照）的子样本中收集了DNA样本，以对13个全基因组关联研究确定的基因座进行基因分型。计算校正的比值比（OR）和95％置信区间（CIs），并通过向统计模型中添加交叉乘积项来获得生殖窗与基因型之间相互作用的P值。结果：对于第一胎的标准化年龄，OR值为1.52（CI，1.36-1.71），比较最高的五分位数和最低的五分位数。 rs10941679（5p12）和rs10483813（RAD51B）的运营商状态似乎改变了这种关系（分别为P = .04和P = .02）。对于生殖寿命，将最高五分位数与最低五分位数进行比较的OR为1.62（CI，1.35-1.95）。在基因型和生殖寿命之间未发现相互作用（所有P> .05）。无论导管型还是小叶型乳腺癌亚型，所有结果均相似。结论：我们的结果表明，生殖窗与患乳腺癌的风险有关，并且这种关联可能因遗传变异而异。

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