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首页> 外文期刊>Annals of epidemiology >Latency and exposure-health associations in Gulf War veterans with early fatigue onsets: a case-control study.
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Latency and exposure-health associations in Gulf War veterans with early fatigue onsets: a case-control study.

机译：患有早期疲劳发作的海湾战争退伍军人的潜伏期和暴露-健康协会：病例对照研究。

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PURPOSE: To see if self-reported exposures were associated with health in early-onset Gulf War illnesses (GWIs) cases and healthy Gulf War veteran controls. METHODS: Forty-nine cases and 44 controls completed questionnaires about wartime exposures and symptoms experienced. Odds ratios were calculated using 2 x 2 tables and logistic regression. The incubation curve of fatigue onsets in cases was drawn to highlight exposure/health associations using Sartwell's method and tested with the Shapiro-Wilk test. The incubation period was defined as the time from arrival in the Persian Gulf to fatigue onset. RESULTS: The incubation curve was right skewed and lognormally distributed (p = 0.48; p > 0.05 indicates lognormality), suggesting an association between a wartime exposure and fatigue. Exposure to oil fire smoke, pesticides, contaminated food or water, dead animals, scud missile attacks, dead bodies, prisoners of war, artillery or small arms fire, and chemical suits was significantly associated with GWIs. Pyridostigmine bromide (PB) was the only continuous exposure significantly associated with GWIs. The odds of having GWIs increased by 1.3% for every PB pill taken (95% confidence interval 1.001-1.02). There were significant trends toward worse health with greater intake of PB. CONCLUSIONS: These analyses suggest that wartime exposures, including exposure to PB, are associated with fatigue.
机译：目的：了解自我报告的暴露是否与早期发作的海湾战争疾病（GWI）病例和健康的海湾战争退伍军人对照有关。方法：49例病例和44例对照者完成了关于战时暴露和所经历症状的问卷调查。使用2 x 2表格和逻辑回归计算赔率。使用Sartwell方法绘制病例疲劳发作的孵育曲线以突出暴露/健康关联，并使用Shapiro-Wilk检验进行测试。潜伏期定义为从到达波斯湾到疲劳发作的时间。结果：孵化曲线右偏且呈对数正态分布（p = 0.48; p> 0.05表示对数正态），表明战时暴露与疲劳之间存在关联。 GWI与暴露于油火烟雾，杀虫剂，受污染的食物或水，死动物，飞毛腿导弹袭击，尸体，战俘，火炮或小型武器着火以及化学服有关。溴吡斯的明溴化物（PB）是唯一与GWI显着相关的连续暴露。每服用一个PB丸，使GWI发生几率增加1.3％（95％置信区间1.001-1.02）。摄入大量PB会导致健康状况恶化的显着趋势。结论：这些分析表明，战时暴露，包括暴露于PB与疲劳有关。

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