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首页> 外文期刊>Annals of epidemiology >Maternal exposures to hazardous waste sites and industrial facilities and risk of neural tube defects in offspring.
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Maternal exposures to hazardous waste sites and industrial facilities and risk of neural tube defects in offspring.

机译：孕产妇接触危险废物场所和工业设施以及后代神经管缺陷的风险。

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PURPOSE: We examined the relationship between maternal proximity to hazardous waste sites and industrial facilities and neural tube defect (NTD) risk. METHODS: Texas Birth Defects Registry cases were linked with their birth or fetal death certificates; controls (without defects) were randomly selected from birth certificates. Distances from maternal addresses at delivery to National Priority List (NPL) and state superfund sites and Toxic Release Inventory (TRI) facilities were determined for 655 cases and 4368 controls. RESULTS: Living within 1 mile of an NPL or state superfund site was not related to NTD risk (adjusted odds ratio [OR] = 1.0; 95% confidence intervals [CI] = 0.6, 1.7). Living within 1 mile of a TRI facility carried a slight risk (adjusted OR = 1.2; 95% CI = 1.0, 1.5). The effect was highest among mothers 35 years and older (OR = 2.7; 95% CI = 1.4, 5.0) and among non-Hispanic white mothers (OR = 1.8; 95% CI = 1.1, 2.8). CONCLUSIONS: Hazardous waste sites posed little risk for NTDs in offspring. Close proximity to industrial facilities with chemical air emissions was associated with NTD risk in some subgroups. Further investigation is needed to determine if the effects are real or due to unresolved confounding or bias.
机译：目的：我们检查了孕妇与危险废物场所和工业设施的距离与神经管缺陷（NTD）风险之间的关系。方法：将德克萨斯州出生缺陷登记处的病例与其出生或胎儿死亡证明书联系起来;从出生证明中随机选择对照（无缺陷）。确定了655例病例和4368例对照从分娩时产妇住址到国家优先清单（NPL）和州超级基金站点以及有毒释放清单（TRI）设施的距离。结果：居住在不良贷款或州超级基金所在地1英里范围内与NTD风险无关（调整后的优势比[OR] = 1.0; 95％置信区间[CI] = 0.6、1.7）。在TRI设施的1英里范围内居住会带来轻微风险（调整后的OR = 1.2; 95％CI = 1.0，1.5）。在35岁及以上的母亲中，效果最高（OR = 2.7; 95％CI = 1.4，5.0）和在非西班牙裔白人母亲中（OR = 1.8; 95％CI = 1.1，2.8）。结论：危险废物场所对后代NTD的危害很小。在某些亚组中，与化学空气排放物紧密接近的工业设施与NTD风险有关。需要进一步研究以确定效果是真实的还是由于未解决的混淆或偏见。

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