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首页> 外文期刊>Annals of epidemiology >Body mass index and mortality in middle-aged Korean women.
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Body mass index and mortality in middle-aged Korean women.

机译：韩国中年妇女的体重指数和死亡率。

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PURPOSE: We sought to evaluate the association between body mass index (BMI) and mortality in Korean women and to determine whether the association differs depending on menopausal status. METHODS: A total of 338,320 Korean women ages 40 to 64 years categorized into seven groups by BMI level were prospectively followed for mortality from approximately 1994 to 2004. RESULTS: Multivariable-adjusted analysis using Cox proportional hazards model showed a U-shaped association between BMI and all-cause deaths, with the lowest risk at BMI between approximately 25 and 26.9 kg/m2, even after excluding earlier deaths, which did not change when we did a stratified analysis according to menopausal status. A U-shaped association was observed between BMI and cancer death, and the risk associated with low BMI decreased significantly after excluding earlier cancer deaths. There was a J-shaped association between BMI and coronary heart disease (CHD) with a significantly increased risk at greater BMI (>26 kg/m2). Additional adjustment for possible biological effects of obesity (i.e., serum total cholesterol, glucose, and systolic blood pressure) changed the U-shaped association between BMI and all-causes mortality into an inverse shape and substantially reduced the size of risk for CHD death associated with high BMI level. In stratified analysis, the association between BMI and CHD was positive linear in women at premenopausal status, whereas it was U-shaped in women at postmenopausal status. CONCLUSIONS: Obesity was associated with an increased risk of mortality in both premenopausal and postmenopausal Korean women, indicating that preventive strategies to control obesity are important even in population with a relatively low mean BMI level.
机译：目的：我们试图评估韩国女性的体重指数（BMI）与死亡率之间的关联，并确定该关联是否根据更年期状态而有所不同。方法：前瞻性追踪了1994年至2004年大约338,320名年龄在40至64岁的韩国女性，按BMI水平分为7组。结果：使用Cox比例风险模型进行的多变量调整分析显示，BMI之间呈U型关联和全因死亡，即使不包括较早的死亡，BMI的最低风险也在25到26.9 kg / m2之间，当我们根据更年期状况进行分层分析时，这一风险没有改变。观察到BMI与癌症死亡之间呈U形关联，排除早期癌症死亡后，与低BMI相关的风险显着降低。 BMI与冠心病（CHD）之间呈J形关联，而BMI升高（> 26 kg / m2）则风险显着增加。肥胖的可能生物学效应（例如，血清总胆固醇，葡萄糖和收缩压）的其他调整将BMI和所有原因的死亡率之间的U型关联改变为倒数形式，并显着降低了与CHD相关的死亡风险具有较高的BMI水平。在分层分析中，绝经前妇女的BMI和CHD呈正线性关系，而绝经后妇女的呈U形。结论：肥胖与绝经前和绝经后韩国女性的死亡风险增加相关，表明即使在平均BMI水平相对较低的人群中，控制肥胖的预防策略也很重要。

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