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首页> 外文期刊>Annals of epidemiology >Effect of urban traffic, individual habits, and genetic polymorphisms on background urinary 1-hydroxypyrene excretion.
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Effect of urban traffic, individual habits, and genetic polymorphisms on background urinary 1-hydroxypyrene excretion.

机译：城市交通，个人习惯和遗传多态性对背景尿液1-羟基py排泄的影响。

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PURPOSE: Potential sources of exposure to polycyclic aromatic hydrocarbons (PAHs) and genetic polymorphisms were investigated in relation to their contribution to interindividual variation in baseline levels of urinary 1-hydroxypyrene (1-OHP) excretion in subjects without occupational exposure to PAHs. METHODS: Urinary excretion of 1-OHP was measured in 114 subjects, including 48 women and 66 men. Questionnaire information was collected on possible environmental and individual sources of PAH exposure. A subset of 70 individuals also was evaluated for a single-nucleotide polymorphism (Ex7+295C-->T) in the cytochrome P-450 1A2 (CYP1A2) gene, and 61 of these also were evaluated for the glutathione transferase T1 (GSTT1) gene polymorphism. RESULTS: 1-OHP values did not show a significant seasonal variability and were unaffected by age; education; body mass index; smoking status, including passive smoking; or the C-->T base substitution in position 295 of exon 7 of the CYP1A2 gene. After reciprocal adjustment with logistic regression, living in a heavily trafficked urban area (odds ratio, 4.9; 95% confidence interval, 1.0-24.9), and frequent intake of grilled meat (odds ratio, 6.9; 95% confidence interval, 1.1-43.5) were significant predictors of background urinary 1-OHP levels of 0.50 microg/g creatinine or greater. Elevated risks also were associated with daily alcohol intake greater than 65 g and the nonnull GSTT1 genotype. CONCLUSION: Our study shows that exposure to urban traffic, dietary habits, and the nonnull GSTT1 genotype may contribute to interindividual variation in background levels of 1-OHP urinary excretion in subjects without occupational exposure to PAHs.
机译：目的：研究在没有职业性暴露于PAHs的受试者中，其对尿中1-羟基py（1-OHP）排泄量基线水平个体间差异的贡献，研究了暴露于多环芳烃（PAHs）和遗传多态性的潜在来源。方法：在114名受试者中测量了1-OHP的尿排泄，包括48名女性和66名男性。收集了有关PAH暴露的可能环境和个体来源的问卷信息。还评估了70个个体的一个子集，用于细胞色素P-450 1A2（CYP1A2）基因中的单核苷酸多态性（Ex7 + 295C-> T），其中61个还评估了谷胱甘肽转移酶T1（GSTT1）基因多态性。结果：1-OHP值没有显示出明显的季节性变化，并且不受年龄的影响;教育;体重指数吸烟状况，包括被动吸烟;或CYP1A2基因第7外显子的295位的C-> T碱基取代。经过logistic回归的对等调整后，居住在人口稠密的城市地区（赔率，4.9; 95％置信区间，1.0-24.9），并频繁摄入烤肉（赔率，6.9; 95％置信区间，1.1-43.5） ）是0.50 microg / g肌酐或更高的背景尿液1-OHP水平的重要预测指标。每日饮酒量超过65克和非空GSTT1基因型也增加了患病风险。结论：我们的研究表明，在没有职业性暴露于PAHs的受试者中，暴露于城市交通，饮食习惯和非无效GSTT1基因型可能导致个体1-OHP尿排泄背景水平的个体差异。

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