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首页> 外文期刊>Annals of epidemiology >Vitamin D for cancer prevention: global perspective.
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Vitamin D for cancer prevention: global perspective.

机译：预防癌症的维生素D：全球视角。

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PURPOSE: Higher serum levels of the main circulating form of vitamin D, 25-hydroxyvitamin D (25(OH)D), are associated with substantially lower incidence rates of colon, breast, ovarian, renal, pancreatic, aggressive prostate and other cancers. METHODS: Epidemiological findings combined with newly discovered mechanisms suggest a new model of cancer etiology that accounts for these actions of 25(OH)D and calcium. Its seven phases are disjunction, initiation, natural selection, overgrowth, metastasis, involution, and transition (abbreviated DINOMIT). Vitamin D metabolites prevent disjunction of cells and are beneficial in other phases. RESULTS/CONCLUSIONS: It is projected that raising the minimum year-around serum 25(OH)D level to 40 to 60 ng/mL (100-150 nmol/L) would prevent approximately 58,000 new cases of breast cancer and 49,000 new cases of colorectal cancer each year, and three fourths of deaths from these diseases in the United States and Canada, based on observational studies combined with a randomized trial. Such intakes also are expected to reduce case-fatality rates of patients who have breast, colorectal, or prostate cancer by half. There are no unreasonable risks from intake of 2000 IU per day of vitamin D(3), or from a population serum 25(OH)D level of 40 to 60 ng/mL. The time has arrived for nationally coordinated action to substantially increase intake of vitamin D and calcium.
机译：目的：维生素D主要循环形式25-羟基维生素D（25（OH）D）的较高血清水平与结肠癌，乳腺癌，卵巢癌，肾癌，胰腺癌，侵袭性前列腺癌和其他癌症的发病率显着降低有关。方法：流行病学发现与新发现的机制相结合，提出了一种新的癌症病因模型，该模型解释了25（OH）D和钙的这些作用。它的七个阶段是分离，启动，自然选择，过度生长，转移，内卷和过渡（缩写为DINOMIT）。维生素D代谢物可防止细胞分离，并在其他阶段有益。结果/结论：预计将全年最低血清25（OH）D水平提高到40至60 ng / mL（100-150 nmol / L），将可预防约58,000例乳腺癌新病例和49,000例乳腺癌新病例。根据观察性研究与一项随机试验相结合，美国和加拿大每年都会发生大肠癌，并且有四分之三的人死于这些疾病。还预期此类摄入量会将患有乳腺癌，结肠直肠癌或前列腺癌的患者的病死率降低一半。每天摄入2000 IU维生素D（3）或人群血清25（OH）D水平为40至60 ng / mL，没有任何不合理的风险。现在是采取全国协调行动以大量增加维生素D和钙摄入量的时候了。

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