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An international case-control study of maternal diet during pregnancy and childhood brain tumor risk: a histology-specific analysis by food group.

机译:孕期和儿童脑瘤风险孕妇饮食的国际病例对照研究:按食物组别进行的组织学分析。

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PURPOSE: Maternal dietary data from an international collaborative case-control study on childhood brain tumors were used to evaluate associations between histology-specific risk and consumption of specific food groups during pregnancy. METHODS: Nine study centers from seven countries contributed 1218 cases and 2223 controls. Most cases were diagnosed between 1982 and 1992 and ranged in age from 0 to 19 years. Dietary consumption was measured as average grams per day. RESULTS: Foods generally associated with increased risk were cured meats, eggs/dairy, and oil products; foods generally associated with decreased risk were yellow-orange vegetables, fresh fish, and grains. The cured meat association was specific to astrocytomas (odds ratio [OR] range=1.8-2.5 across astrocytoma subtypes for 4th vs. 1st quartile of consumption, p trends
机译:目的:一项关于儿童脑肿瘤的国际协作病例对照研究的孕产妇饮食数据被用于评估妊娠期间组织学特异性风险与特定食物类别消费之间的关联。方法:来自七个国家的9个研究中心贡献了1218例病例和2223例对照。大多数病例在1982年至1992年之间被诊断出,年龄在0至19岁之间。饮食消耗以每天平均克数衡量。结果:通常与风险增加相关的食物是腌制的肉,蛋/奶制品和油产品;通常与降低风险相关的食物是橙黄色蔬菜,新鲜鱼和谷物。腌制肉的关联特定于星形细胞瘤(占食用星形细胞瘤亚型的第4个与第1个四分位数的比值比[OR]范围= 1.8-2.5,p趋势<或= 0.03)和室管膜瘤(OR为2.0; 95%置信区间( CI),第4比1(第4个四分位数)为0.4-2.9; p趋势= 0.03),其大小与先前报道的将孕妇腌制肉类食用与星形胶质风险增加有关的OR相似。其他与组织学相关的关联性包括十字花科蔬菜发生间变性星形细胞瘤的风险降低(OR:0.4;第一四分位数为95%CI,0.3-0.7; p趋势<0.0001);鲜鱼发生星形胶质瘤的风险降低(OR, 0.6; 95%CI,第4个与第1个四分位数的比例为0.5-0.9; p趋势= 0.008),以及油品引起的成髓细胞瘤的风险增加(OR,1.5; 95%CI,第4个与1(st)的比例为1.0-2.2四分位数; p趋势= 0.005)。结论:这些结果表明,不仅需要通过脑肿瘤组织学进行饮食分析,而且需要通过广泛食物组中的特定食物进行饮食分析。

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