• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >A brief history of vitamin d and cancer prevention.
【24h】

A brief history of vitamin d and cancer prevention.

机译：维生素D和癌症预防的简史。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To review the history of vitamin D and its use in cancer prevention. METHODS: The literature on published studies of vitamin D and its role in human health was reviewed and summarized. RESULTS: The modern history of vitamin D began in the mid-1800s, when it was noticed that city children were more likely to have rickets than rural children. Half a century later, Palm reported that children raised in sunny climates virtually never developed rickets. McCollum isolated vitamin D, and Windaus its precursors, receiving the Nobel Prize. Other scientists later observed that people with skin cancer had lower prevalence of nonskin cancers, and that lower overall mortality rates from all internal cancers combined existed in sunnier areas. These observations went largely unnoticed, and the field stagnated until 1970, when maps were created of cancer mortality rates. Through study of these maps, Cedric and Frank Garland of Johns Hopkins University reported a strong latitudinal gradient for colon cancer mortality rates in 1980, and hypothesized that higher levels of vitamin D compounds in the serum of people in the south were responsible, and that calcium intake also would reduce incidence. Edward Gorham and colleagues carried out cohort and nested studies, including the first study that found an association of a serum vitamin D compound with reduced cancer risk. William B. Grant then carried out numerous ecologic studies that extended the vitamin D-cancer theory to other cancers. CONCLUSIONS: The history of the role of vitamin D in human health is rich and much of that history is yet to be written not only by scientists, but by policy makers with the vision and leadership necessary to bridge the gap between research and policy.
机译：目的：回顾维生素D的历史及其在癌症预防中的用途。方法：综述并总结了有关维生素D及其在人体健康中作用的已发表研究的文献。结果：维生素D的现代历史始于1800年代中期，当时人们注意到城市儿童比农村儿童更容易患病。半个世纪后，Palm报告说，在阳光明媚的气候中长大的孩子几乎没有developed病。 McCollum分离出维生素D，而Windaus分离出维生素D，获得了诺贝尔奖。后来其他科学家观察到，皮肤癌患者非皮肤癌的患病率较低，在所有阳光明媚的地区，所有内部癌症的综合死亡率均较低。这些发现在很大程度上没有引起注意，直到1970年，当绘制了癌症死亡率图时，该领域一直停滞不前。通过研究这些地图，约翰·霍普金斯大学的塞德里克和弗兰克·加兰德报告了1980年结肠癌死亡率的强纬度梯度，并假设南方人群的血清中维生素D化合物含量较高，而钙摄入也会减少发病率。爱德华·戈勒姆（Edward Gorham）及其同事进行了队列研究和嵌套研究，包括第一项研究发现血清维生素D化合物与降低的癌症风险相关。威廉·格兰特（William B. Grant）随后进行了许多生态学研究，将维生素D癌症理论扩展到了其他癌症。结论：维生素D在人类健康中的作用历史悠久，不仅有科学家，而且还有决策者必须具备弥合维生素D的历史，他们的远见卓识和领导才能弥合研究与政策之间的鸿沟。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号