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Age-period-cohort analysis of hepatocellular carcinoma mortality in Taiwan, 1976-2005.

机译:1976-2005年台湾肝细胞癌死亡率的年龄同期队列分析。

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PURPOSE: Hepatocellular carcinoma (HCC) is one of the most common malignant primary liver tumors worldwide. A previous study showed a decline in pediatric HCC in Taiwan after the universal vaccination program was initiated in 1984. We investigated whether the recent change in HCC mortality in Taiwan represented a short-term fluctuation or an emerging long-term decline trend. METHODS: An age-period-cohort analysis was conducted to show HCC mortality trends between 1976 and 2005. A total of 121,643 HCC mortality cases (92,926 males and 28,717 females) of individuals older than 40 years of age was used in the analyses. RESULTS: Results indicate an increasing secular trend in HCC mortality over the last three decades in people aged 60 years and above. In the age group of >85 years old, the mortality rate for males and females was 7.47 (95% confidence interval [95% CI]: 6.24-8.94) and 25.0 (95% CI: 15.5-40.2) times greater than in the youngest age group (40-44), respectively. The relative risk of dying fromHCC in the period 2001-2005 was 1.36 (95% CI: 1.23-1.50) for males compared to the 1976-1980 time period, and 1.42 (95% CI: 1.17-1.72) for females compared to the 1986-1990 time period. A strong birth-cohort effect was also found. Individuals born around 1936 had the highest risk of dying from HCC. CONCLUSION: These findings imply that important determinants of HCC may occur early in life, with their effects only becoming apparent much later.
机译:目的:肝细胞癌(HCC)是全世界最常见的恶性原发性肝癌之一。先前的一项研究表明,1984年开始实施全民疫苗接种计划后,台湾儿童HCC有所下降。我们调查了台湾最近HCC死亡率的变化是短期的波动还是长期的下降趋势。方法:进行了一项年龄组分析,以显示1976年至2005年之间的HCC死亡率趋势。分析中使用了121,643例40岁以上的HCC死亡病例(男性92,926例,女性28,717例)。结果:结果表明,在过去的三十年中,年龄在60岁以上的人的HCC死亡率呈长期趋势。在大于85岁的年龄组中,男性和女性的死亡率分别是男性和女性的7.47倍(95%置信区间[95%CI]:6.24-8.94)和25.0倍(95%CI:15.5-40.2)倍。最小年龄组(40-44)。与1976-1980年相比,男性死于HCC的相对风险为1.36(95%CI:1.23-1.50),而女性为1.42(95%CI:1.17-1.72)。 1986-1990年。还发现了强大的出生队列效应。 1936年左右出生的人死于肝癌的风险最高。结论:这些发现表明,肝癌的重要决定因素可能在生命的早期发生,其影响要到很久以后才显现出来。

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