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Nutrient-based dietary patterns and pancreatic cancer risk

机译：基于营养的饮食模式和胰腺癌的风险

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Purpose: Few data are available on the role of combinations of foods and/or nutrients on pancreatic cancer risk. To add further information on dietary patterns potentially associated to pancreatic cancer, we applied an exploratory principal component factor analysis on 28 major nutrients derived from an Italian case-control study. Methods: Cases were 326 incident pancreatic cancer cases and controls 652 frequency-matched controls admitted to hospital for non-neoplastic diseases. Dietary information was collected through a validated and reproducible food frequency questionnaire. Multiple logistic regression models adjusted for sociodemographic variables and major recognized risk factors for pancreatic cancer were used to estimate the odds ratios (OR) of pancreatic cancer for each dietary pattern. Results: We identified four dietary patterns-named " animal products," " unsaturated fats," " vitamins and fiber," and " starch rich," that explain 75% of the total variance in nutrient intake in this population. After allowing for all the four patterns, positive associations were found for the animal products and the starch rich patterns, the OR for the highest versus the lowest quartiles being 2.03 (95% confidence interval [CI], 1.29-3.19) and 1.69 (95% CI, 1.02-2.79), respectively; an inverse association emerged for the vitamins and fiber pattern (OR, 0.55; 95% CI, 0.35-0.86), whereas no association was observed for the unsaturated fats pattern (OR, 1.13; 95% CI, 0.71-1.78). Conclusions: A diet characterized by a high consumption of meat and other animal products, as well as of (refined) cereals and sugars, is positively associated with pancreatic cancer risk, whereas a diet rich in fruit and vegetables is inversely associated. ? 2013 Elsevier Inc.
机译：目的：关于食物和/或营养物的组合对胰腺癌风险的作用的数据很少。为了增加有关可能与胰腺癌相关的饮食模式的信息，我们对来自意大利病例对照研究的28种主要营养素进行了探索性主成分因子分析。方法：病例326例为胰腺癌，对照为652例非肿瘤性疾病的频率匹配对照。通过有效且可重复的食物频率问卷收集饮食信息。使用针对社会人口学变量和胰腺癌的主要公认危险因素进行调整的多个logistic回归模型，以估算每种饮食方式的胰腺癌的优势比（OR）。结果：我们确定了四种饮食模式，分别称为“动物产品”，“不饱和脂肪”，“维生素和纤维”和“富含淀粉”，这些饮食模式解释了该人群营养摄入总量的75％。在考虑所有四种模式后，发现动物产品和富含淀粉的模式呈正相关，最高四分位数与最低四分位数的OR分别为2.03（95％置信区间[CI]，1.29-3.19）和1.69（95） ％CI，1.02-2.79）;维生素和纤维形态的反相关关系出现（OR，0.55; 95％CI，0.35-0.86），而不饱和脂肪形态则没有相关性（OR，1.13; 95％CI，0.71-1.78）。结论：以肉类和其他动物产品以及（精制的）谷物和糖类的大量食用为特征的饮食与胰腺癌的风险呈正相关，而富含水果和蔬菜的饮食则与胰腺癌的发生呈正相关。 ？ 2013爱思唯尔公司

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