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首页> 外文期刊>Annals of epidemiology >Prenatal exposure to selective serotonin reuptake inhibitors and childhood overweight at 7 years of age
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Prenatal exposure to selective serotonin reuptake inhibitors and childhood overweight at 7 years of age

机译：产前暴露于选择性5-羟色胺再摄取抑制剂和7岁儿童超重

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Purpose: To investigate a possible association between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and childhood overweight at 7 years of age. Methods: Information on pregnancy exposures and prevalence of childhood overweight at 7 years of age was obtained from the Danish National Birth Cohort. Overweight was classified as body mass index >85th percentile, based on age and sex. Based on an a priori hypothesis, we conducted analyses stratified by child sex to examine sex-specific differences. Results: Of eligible pregnant women, 127 reported using an SSRI, 490 reported having a psychiatric illness but no psychotropic medication use, and 35,568 reported no psychiatric illness and no psychotropic medication use. In comparison to children of mothers with a psychiatric illness but no SSRI use during pregnancy, prenatal SSRI exposure overall was not associated with an increased risk of childhood overweight (adjusted prevalence ratio [aPR] 1.12; 95% confidence interval 0.71 to 1.77). However, when stratified according to child sex, an increased risk was observed among males (aPR 1.78; 95% CI, 1.01 to 3.12) but not females (aPR 0.86; 95% CI, 0.37 to 1.99). In contrast, female children of mothers with a psychiatric illness but no SSRI use during pregnancy were more likely to be overweight than female children of unexposed mothers (aPR 1.45; 95% CI, 1.05 to 2.02). This association was not mirrored among males (aPR 1.06; 95% CI, 0.76 to 1.50). Conclusions: We observed the potential for opposing sex-specific differences in the long-term effects of prenatal exposure to SSRI use and/or maternal psychiatric illness on childhood overweight. Limitations of the present study suggest that further research in this area may be warranted with larger sample sizes and longer follow-up.
机译：目的：探讨产前选择性5-羟色胺再摄取抑制剂（SSRI）暴露与7岁儿童超重之间的可能联系。方法：从丹麦国家出生队列获得有关妊娠暴露和7岁儿童超重患病率的信息。根据年龄和性别，超重被分类为体重指数> 85％。基于先验假设，我们进行了按儿童性别分层的分析，以检查特定性别的差异。结果：在合格孕妇中，有127名报告使用SSRI，490名报告患有精神疾病但未使用精神药物，还有35,568名报告未患有精神疾病且未使用精神药物。与患有精神疾病但在怀孕期间未使用SSRI的母亲的孩子相比，产前SSRI的总体暴露与儿童超重的风险增加无关（调整患病率[aPR] 1.12; 95％的置信区间0.71至1.77）。但是，按儿童性别分层时，男性患病风险增加（aPR 1.78; 95％CI，1.01至3.12），而女性患病风险却升高（aPR 0.86; 95％CI，0.37至1.99）。相比之下，患有精神疾病但在怀孕期间未使用SSRI的母亲的女童比未接触母亲的女童更可能超重（aPR 1.45; 95％CI，1.05至2.02）。男性之间没有这种关联（aPR 1.06; 95％CI，0.76至1.50）。结论：我们观察到在产前暴露于SSRI和/或产妇精神病对儿童超重的长期影响中，有可能反对性别差异。本研究的局限性表明，可能需要更大的样本量和更长的随访时间来进行这一领域的进一步研究。

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