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首页> 外文期刊>Annals of epidemiology >Self-reported hepatitis and non-Hodgkin lymphoma: an analysis according to the time since hepatitis diagnosis.
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Self-reported hepatitis and non-Hodgkin lymphoma: an analysis according to the time since hepatitis diagnosis.

机译：自我报告的肝炎和非霍奇金淋巴瘤：根据自肝炎诊断以来的时间进行分析。

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PURPOSE: Using data from the Selected Cancers Study, the authors tested whether the association between hepatitis infection and non-Hodgkin lymphoma (NHL) varied according to the time since the diagnosis of hepatitis. METHODS: Cases were 1177 men ages 32-60 diagnosed with NHL between 1984 and 1988. Controls were men with no history of NHL who were frequency-matched to lymphoma cases by age and cancer registry (n = 1852). Interviews were conducted to collect data on risk factors including history of hepatitis. No information on types of hepatitis was obtained. RESULTS: Logistic regression analyses indicated that history of hepatitis diagnosed 3 or more years prior to the reference date was not a significant risk factor for NHL (OR [odds ratio] = 0.92, 95% CI: 0.63-1.35). In contrast, men with a history of hepatitis diagnosed within 3 years prior to the diagnosis date had more than a five-fold increased risk of NHL (OR = 5.77, 95% CI: 1.99-16.74). CONCLUSIONS: Although the study was limited by lack of information on different types of hepatitis, the increased OR for hepatitis diagnosed more closely to the NHL diagnosis suggests that the reported association between hepatitis and NHL might partly result from increased detection of NHL in patients with recently reported hepatitis virus infection.
机译：目的：使用来自选定癌症研究的数据，作者测试了肝炎感染与非霍奇金淋巴瘤（NHL）之间的关联是否根据诊断肝炎的时间而有所不同。方法：病例为1984年至1988年之间被诊断为NHL的1177名32-60岁男性。对照组为无NHL病史的男性，其年龄和癌症登记与淋巴瘤病例的频率匹配（n = 1852）。进行访谈以收集包括肝炎病史在内的危险因素的数据。没有获得有关肝炎类型的信息。结果：Logistic回归分析表明，在参考日期之前3年或更早诊断出的肝炎病史不是NHL的重要危险因素（OR [优势比] = 0.92，95％CI：0.63-1.35）。相比之下，在诊断日期之前3年内被诊断出患有肝炎的男性患NHL的风险增加了5倍以上（OR = 5.77，95％CI：1.99-16.74）。结论：尽管该研究由于缺乏关于不同类型肝炎的信息而受到限制，但被诊断为与NHL诊断更接近的肝炎OR升高表明，据报道，肝炎与NHL之间的相关性可能部分是由于近期患有NHL的患者检测增加报告肝炎病毒感染。

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