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Vitamin D and pancreatic cancer.

机译：维生素D和胰腺癌。

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Sun exposure has been associated with lower death rates for pancreatic cancer in ecological studies. Skin exposure to solar ultraviolet B radiation induces cutaneous production of precursors to 25-hydroxy (OH) vitamin D (D) and is considered the primary contributor to vitamin D status in most populations. Pancreatic islet and duct cells express 25-(OH) D(3)-1alpha-hydroxylase that generates the biologically active 1,25-dihydroxy(OH)(2) D form. Thus, 25(OH)D concentrations could affect pancreatic function and possibly pancreatic cancer etiology. Serum 25-(OH)D is the major circulating vitamin D metabolite and is considered the best indicator of vitamin D status as determined by the sun and diet. Although recent prospective epidemiologic studies of higher predicted vitamin D status score and vitamin D intake and pancreatic cancer risk suggest protective associations, a nested case-control study showed a significant 3-fold increased risk for pancreatic cancer with higher vitamin D status. Limitations of these studies include the former do not measure vitamin D status on pancreatic cancer cases and the later was conducted in a male smoker population. More research is needed, particularly examination of pre-diagnostic vitamin D status and risk of pancreatic cancer, prior to conclusions for vitamin D's potential role in the etiology of this highly fatal cancer.
机译：在生态学研究中，日光照射与胰腺癌死亡率降低相关。皮肤暴露于太阳紫外线B辐射会诱导皮肤产生25-羟基（OH）维生素D（D）的前体，并且被认为是大多数人群中维生素D状况的主要贡献者。胰岛和胰管细胞表达25-（OH）D（3）-1α-羟化酶，该酶产生具有生物活性的1,25-二羟基（OH）（2）D形式。因此，25（OH）D浓度可能会影响胰腺功能，并可能影响胰腺癌的病因。血清25-（OH）D是循环的主要维生素D代谢产物，被阳光和饮食所确定，被认为是维生素D状态的最佳指标。尽管最近对更高的维生素D状态评分和维生素D摄入量与胰腺癌风险进行预测的前瞻性流行病学研究表明存在保护性关联，但巢式病例对照研究显示，维生素D状态较高的胰腺癌风险显着增加了3倍。这些研究的局限性包括前者不能测量胰腺癌病例中的维生素D状况，而后者是在男性吸烟者人群中进行的。在得出有关维生素D在这种高度致命癌症的病因中的潜在作用的结论之前，还需要进行更多的研究，特别是检查维生素D的诊断前状态和胰腺癌的风险。

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