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首页> 外文期刊>Annals of epidemiology >#85 Association of serum antibodies to the helicobacter pylori caga antigen with precancerous gastric lesions in chinese populations with contrasting gastric cancer rates.
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#85 Association of serum antibodies to the helicobacter pylori caga antigen with precancerous gastric lesions in chinese populations with contrasting gastric cancer rates.

机译：＃85在中国人群中，幽门螺杆菌caga抗原的血清抗体与胃癌前病变与胃癌发生率的相关性。

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摘要

PURPOSE: To assess whether serologic markers of Helicobacter pylori infection can account for the differences in prevalence of advanced precancerous gastric lesions (APGL) between two rural Chinese villages.METHODS: We studied asymptomatic adult subjects in Bei Duan village (N = 196) in Linqu County (a high-risk area for gastric cancer) and in Shi Huang village (N = 192) in Cangshan County (a low-risk area for gastric cancer) in Shandong Province, China. Prevalence of APGL was assessed by microscopic examination of endoscopic stomach biopsies. Enzyme-linked immunosorbent assays (ELISA) were used to detect IgG to the H. pylori whole-cell antigen, and to the CagA protein. A logistic regression model was used to quantify the role of the two H. pylori seromarkers in explaining the differences in prevalence of APGL between the two villages, after adjusting for age and sex.RESULTS: The prevalence of APGL was much greater in Bei Duan than in Shi Huang. Although H. pylori seroprevalence by the whole-cell ELISA was similar in the two populations, seroprevalence of CagA was significantly greater in Bei Duan. Although age, sex, and both H. pylori seromarkers were associated with APGL in the logistic regression model, the effect of village of residence remained strong after adjustment for all four covariates.CONCLUSION: Only a relatively small proportion of the variation in prevalence of APGL in the rural Chinese population can be explained by differences in H. pylori seroprevalence, or by differences in CagA seroprevalence.
机译：目的：评估幽门螺杆菌感染的血清学指标是否可以解释两个中国乡村之间晚期胃癌前病变（APGL）的患病率差异。方法：我们在临qu市北段村（N = 196）研究了无症状成人受试者。中国山东省苍山县（胃癌的低风险地区）的县（胃癌高风险地区）和石黄村（N = 192）。通过内镜胃活检的显微镜检查评估APGL的患病率。酶联免疫吸附试验（ELISA）用于检测幽门螺杆菌全细胞抗原和CagA蛋白的IgG。在对年龄和性别进行调整后，使用逻辑回归模型量化了这两种幽门螺杆菌血清标志物在解释两个村庄之间APGL流行率差异中的作用。结果：北段的APGL流行率远高于在石黄。尽管通过全细胞ELISA检测的幽门螺杆菌血清阳性率在两个人群中相似，但北段的CagA血清阳性率明显更高。尽管在Logistic回归模型中年龄，性别和两个幽门螺杆菌血清标志物均与APGL相关，但在对所有四个协变量进行调整后，居住村落的影响仍然很强。结论：APGL患病率变化的比例相对较小中国农村人口中幽门螺杆菌血清阳性率的差异或CagA血清阳性率的差异可以解释这一现象。

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