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首页> 外文期刊>Annals of epidemiology >Are statin medications associated with lower urinary tract symptoms in men and women? Results from the Boston Area Community Health (BACH) Survey.
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Are statin medications associated with lower urinary tract symptoms in men and women? Results from the Boston Area Community Health (BACH) Survey.

机译：他汀类药物与男女的下尿路症状有关吗？波士顿地区社区健康（BACH）调查的结果。

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PURPOSE: Statins may ameliorate lower urinary tract symptoms (LUTS) through anti-inflammatory or other pathways. We investigated the association between statin use and storage, voiding, and overall LUTS symptoms. METHODS: The Boston Area Community Health Survey is an epidemiologic study of Boston, MA residents (2301 men; 3202 women) 30-79 years of age. LUTS, voiding, and storage symptoms were ascertained through an interviewer-administered questionnaire and defined as scores of greater than or equal to 8, greater than or equal to 5, and greater than or equal to 4, respectively, on relevant components of the American Urologic Association Symptom Index. Participants were included if they had a history of provider-diagnosed high cholesterol or recently used statin medications (n = 1346). Associations were estimated using odds ratios (ORs) and 95% confidence intervals (CI) from multivariate logistic regression. RESULTS: In multivariate models, statin use had no association with LUTS (OR= 1.03, 95% CI: 0.70, 1.51) among women. No associations were observed for any LUTS among younger (<60) men, but among older (60+) men, we observed significant inverse associations for voiding (OR= 0.23, 95% CI: 0.08, 0.66), storage (OR = 0.24, 95% CI: 0.11, 0.56), and overall LUTS (OR = 0.15, 95% CI: 0.05, 0.44). CONCLUSIONS: Our results suggest that use of statins is associated with a lower prevalence of urologic symptoms among older men but not among women or younger men.
机译：目的：他汀类药物可通过抗炎或其他途径改善下尿路症状（LUTS）。我们调查了他汀类药物的使用与储存，排尿和总体LUTS症状之间的关联。方法：波士顿地区社区健康调查是对30-79岁的马萨诸塞州波士顿居民（2301名男性; 3202名女性）进行的流行病学研究。通过面试官管理的问卷确定LUTS，排尿和贮藏症状，并将其定义为美国人相关成分的得分分别大于或等于8，大于或等于5和大于或等于4。泌尿科协会症状指数。如果参与者有提供者诊断的高胆固醇病史或最近使用他汀类药物（n = 1346），则包括这些参与者。关联性是根据多元逻辑回归使用比值比（OR）和95％置信区间（CI）估算的。结果：在多变量模型中，女性中他汀类药物的使用与LUTS无关（OR = 1.03，95％CI：0.70，1.51）。在年轻（<60岁）的男性中未观察到任何LUTS的关联，但是在年长（60岁以上）的男性中，我们观察到排尿（OR = 0.23，95％CI：0.08，0.66），储存（OR = 0.24）的显着反相关。 ，95％CI：0.11、0.56）和总体LUTS（OR = 0.15，95％CI：0.05、0.44）。结论：我们的结果表明，他汀类药物的使用与老年男性中泌尿科症状的患病率较低有关，但与女性或年轻男性无关。

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