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首页> 外文期刊>Annals of epidemiology >alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2.
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alcohol, smoking, and caffeine in relation to fecundability, with effect modification by NAT2.

机译：酒精，吸烟和咖啡因与生育力有关，并通过NAT2进行效果修改。

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PURPOSE: Common polymorphisms in the N-acetyltransferase-2 (NAT2) metabolic enzyme determine slow or rapid acetylator phenotypes. We investigated the effects of alcohol, smoking, and caffeine on fecundability, and determined whether the effects were modified by NAT2. METHODS: Three NAT2 polymorphisms were genotyped in 319 women office workers participating in a prospective pregnancy study (1990-1994). Women were ages 20-41 and at risk for pregnancy. Discrete-time survival analysis was used to determine the effects of alcohol, smoking, and caffeine on fecundability and evaluate effect modification by NAT2. RESULTS: We followed 319 women (161 slow acetylators, 158 rapid) for an average of 8 menstrual cycles, resulting in 124 pregnancies. There was no effect of caffeine on fecundability. Drinking >/=1 alcoholic drink per day and current smoking were significantly associated with reduced fecundability, but only among slow acetylators (adjusted fecundability odds ratio [FOR] for smoking = 0.34; 95% confidence interval, 0.22-0.90; adjusted FOR for >/=1 drink per day = 0.20; 0.05-0.92). There was no effect among rapid acetylators. CONCLUSIONS: NAT2 status significantly modified the effects of alcohol and smoking on fecundability, emphasizing the importance of incorporating genetic and metabolic information in studies of reproductive health. Replication of this study is warranted.
机译：目的：N-乙酰基转移酶2（NAT2）代谢酶中常见的多态性决定了慢速或快速乙酰化剂表型。我们调查了酒精，吸烟和咖啡因对生育力的影响，并确定了NAT2是否会改变这些影响。方法：在参加前瞻性妊娠研究（1990-1994年）的319名女性上班族中，对三种NAT2基因多态性进行了基因分型。妇女年龄在20-41岁之间，有怀孕风险。离散时间生存分析用于确定酒精，吸烟和咖啡因对生育力的影响，并评估NAT2对效果的影响。结果：我们追踪了319名妇女（161名慢速乙酰化剂，158名快速乙酰化剂），平均8个月经周期，结果怀孕124例。咖啡因对生育能力没有影响。每天饮酒> / = 1酒精饮料和当前吸烟与生育能力降低显着相关，但仅在慢速乙酰化剂中（吸烟的经调整生育能力优势比[FOR] = 0.34; 95％置信区间0.22-0.90;经调整FOR> / = 1每天的饮料= 0.20; 0.05-0.92）。快速乙酰化剂之间没有作用。结论：NAT2的状态极大地改变了酗酒和吸烟对生育能力的影响，强调了将遗传和代谢信息纳入生殖健康研究的重要性。有必要重复这项研究。

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