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首页> 外文期刊>Annals of epidemiology >Diagnostic x-rays and risk of epithelial ovarian carcinoma in jews.
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Diagnostic x-rays and risk of epithelial ovarian carcinoma in jews.

机译：犹太人的诊断性X射线和上皮性卵巢癌的风险。

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PURPOSE: To test the hypothesis that there would be ethnic differences in susceptibility to ionizing radiation from diagnostic x-rays.METHODS: In a hospital-based study we compared reports of diagnostic x-rays to the lower abdomen and pelvis in incident cases of epithelial ovarian carcinoma (N = 161), community controls (N = 156) and convenience controls (N = 87).RESULTS: Thirty-nine per cent of cases and 31% of controls recalled x-rays more than 10 years before; 27% of cases and 14% of controls reported four Jewish grandparents. Comparing the cases with community controls, the odds ratio (95% confidence interval) for Jews versus non-Jews among women reporting no x-rays was 1.02 (0.37-2.79); among women reporting x-rays the estimate for Jews was 8.91 (2.00-39.6). Consistent results were seen with inclusion of convenience controls. Jewish cases reported an excess of pelvic diagnostic x-rays from age 20 onward and an excess of barium enemas and pyelograms.CONCLUSIONS: These preliminary findings require confirmation in other studies. They suggest that the known excess risk of this carcinoma in Jews might be associated with exposure to x-rays and add to a previous observation of an altered susceptibility to ionizing radiation in Jews. If confirmed, they would suggest a need for continued vigilance to evaluate the risks and benefits of diagnostic x-rays in individuals, regardless of ethnic origin, who might carry mutations in DNA repair genes.
机译：目的：为了检验关于诊断性X射线对电离辐射敏感性的种族差异的假设。方法：在一项基于医院的研究中，我们比较了上皮事件中诊断性X射线与下腹部和骨盆的报告结果：卵巢癌（N = 161），社区对照（N = 156）和便利对照（N = 87）。结果：39％的病例和31％的对照者回忆了10年前的X射线; 27％的病例和14％的对照报告了四名犹太祖父母。与没有社区检查的妇女相比，没有X射线检查的女性中，犹太人与非犹太人的比值比（95％置信区间）为1.02（0.37-2.79）;报告X射线照片的女性中，犹太人的估计数为8.91（2.00-39.6）。包含便利控件后，结果一致。从20岁开始，犹太人病例报告了骨盆诊断X射线过多，钡灌肠和肾盂造影图过多。结论：这些初步发现需要其他研究证实。他们认为，已知在犹太人中罹患这种癌症的风险可能与X射线的暴露有关，并增加了先前对犹太人对电离辐射敏感性变化的观察。如果得到证实，他们将建议需要继续保持警惕，以评估个体中诊断X射线的风险和益处，而不论其种族血统如何，他们都可能携带DNA修复基因的突变。

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