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首页> 外文期刊>Annals of epidemiology >Triglyceride and coronary heart disease mortality in a 24-year follow-up study in Xi'an, China.
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Triglyceride and coronary heart disease mortality in a 24-year follow-up study in Xi'an, China.

机译:在中国西安进行的一项为期24年的随访研究中,甘油三酸酯和冠心病的死亡率。

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PURPOSE: To study whether serum triglyceride (TG) was associated with coronary heart disease (CHD) mortality. METHODS: A cohort analytic study carried out in a machinery factory in Xi'an, China on 1696 subjects aged 35 years or above (1124 men and 572 women) examined in 1976 and followed up till 2000. RESULTS: At baseline, the mean serum total cholesterol (TC) and triglyceride (TG) was 4.64 and 1.16 mmol/L in men, 4.62 and 1.10 mmol/L in women, respectively. Three hundred six (239 men, 67 women) had died within 37,781 person-years of follow-up, with 49 CHD deaths (36 male, 13 female). The relative risk (95% confidence interval) of CHD mortality per mmol/L increase in TG was 2.13 (1.46-3.17) after adjusting for age, marital status, occupation, education, systolic blood pressure and TC. Dose-response relationship between TG levels by tertiles and CHD risk was found. Stratified analyses showed TG was an independent predictor for CHD mortality in subjects with lower or higher TC. CONCLUSIONS: Chinese had lower levels of TC and TG than Western populations. This study provides new evidence that TG is an independent risk factor of CHD in subjects with lower or higher TC levels, and supports the lowering of cut-off value for elevated triglyceride.
机译:目的:研究血清甘油三酸酯(TG)是否与冠心病(CHD)死亡率相关。方法:一项队列分析研究是在1976年在中国西安市的一家机械厂中对35岁及以上的1696名受试者(1124名男性和572名女性)进行了研究,并随访至2000年。结果:在基线时,平均血清男性的总胆固醇(TC)和甘油三酸酯(TG)分别为4.64和1.16 mmol / L,女性为4.62和1.10 mmol / L。在随访的37,781人年内,三百零六名(239名男性,67名女性)死亡,其中49名冠心病死亡(男36例,女13例)。调整年龄,婚姻状况,职业,学历,收缩压和TC后,每mmol / L TG升高,CHD死亡率的相对危险度(95%置信区间)为2.13(1.46-3.17)。发现三分位数的TG水平与CHD风险之间存在剂量反应关系。分层分析显示,TG是TC较低或较高的受试者CHD死亡率的独立预测因子。结论:中国人的TC和TG水平低于西方人。这项研究提供了新的证据,TG是较低或较高TC水平受试者中CHD的独立危险因素,并支持降低甘油三酯升高的临界值。

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