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首页> 外文期刊>Anti-infective agents >Role of bactericidal/permeability-increasing protein (BPI) in sepsis and liver cirrhosis, and its clinical implications
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Role of bactericidal/permeability-increasing protein (BPI) in sepsis and liver cirrhosis, and its clinical implications

机译：杀菌/通透性增强蛋白（BPI）在败血症和肝硬化中的作用及其临床意义

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Background: Bactericidal/permeability-increasing protein (BPI) is a nat-ural cationic protein, which is stored in the polymorphonuclear leucocyte granules. It exerts anti-infective actions through damaging bacterial membranes, neutralizing microbial endotoxins, and promoting phagocytosis of gram-negative bacteria. Con-sequently, its role in sepsis initially raised much hope in infection control. On the other hand, patients with liver cirrhosis present an important risk of sepsis induced by gram-negative microorganism, especially in advanced stages. Methods: MEDLINE was searched for terms including BPI, endotoxins, lipopoly-saccharides, lipopolysaccharide-binding protein, AND sepsis OR liver cirrhosis. Be-sides, trials addressing clinical BPI implication were retrieved and analyzed. Results: Endotoxemia is frequently elevated in sepsis, in alcoholic liver disease, and in liver cirrhosis. BPI expression is higher in liver cirrhosis patients than in healthy individuals, with a significant increase in patients who present a more severe disease. Contrariwise, most clinical studies failed to show any substantial role of BPI in treating sepsis. Conclusion: This review describes the role of BPI and some other proteins involved in sepsis, with a special focus on patients with alcoholic liver diseases. It outlines their mechanisms, indicates alterations associated with their deficiency, and explains obstacles that restrained their therapeutic use.
机译：背景：杀菌/通透性增加蛋白（BPI）是天然阳离子蛋白，存储在多形核白细胞颗粒中。它通过破坏细菌膜，中和微生物内毒素和促进革兰氏阴性细菌的吞噬作用发挥抗感染作用。因此，其在脓毒症中的作用最初在感染控制中引起了很大希望。另一方面，肝硬化患者表现出由革兰氏阴性微生物诱发败血症的重要风险，尤其是在晚期。方法：在MEDLINE中搜索包括BPI，内毒素，脂多糖，脂多糖结合蛋白，败血症或肝硬化在内的术语。此外，检索并分析了涉及临床BPI含义的试验。结果：败血症，酒精性肝病和肝硬化通常会导致内毒素血症升高。肝硬化患者中BPI的表达高于健康个体，而病情更严重的患者中BPI的表达显着增加。相反，大多数临床研究未能显示BPI在治疗败血症中具有任何实质性作用。结论：这篇综述描述了BPI和其他一些蛋白在脓毒症中的作用，特别关注酒精性肝病患者。它概述了它们的机制，指出了与它们缺乏有关的改变，并解释了限制其治疗用途的障碍。

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