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首页> 外文期刊>Acta physiologica >The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity
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The bitter truth about bitter taste receptors: beyond sensing bitter in the oral cavity

机译：关于苦味觉感受器的苦涩真相：超越了口腔中的苦涩感

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摘要

The bitter taste receptor (TAS2R)-family of G-protein-coupled receptors has been identified on the tongue as detectors of bitter taste over a decade ago. In the last few years, they have been discovered in an ever growing number of extra-oral tissues, including the airways, the gut, the brain and even the testis. In tissues that contact the exterior, protective functions for TAS2Rs have been proposed, in analogy to their function on the tongue as toxicity detector. However, TAS2Rs have also been found in internal organs, suggesting other roles for these receptors, perhaps involving as yet unidentified endogenous ligands. The current review gives an overview of the different proposed functions for TAS2Rs in tissues other than the oral cavity; from appetite regulation to the treatment of asthma, regulation of gastrointestinal motility and control of airway innate immunity.
机译：G蛋白偶联受体的苦味受体（TAS2R）家族已在舌头上鉴定为十多年苦味检测器。在过去的几年中，它们在越来越多的口腔外组织中被发现，包括气道，肠道，大脑甚至睾丸。在接触外部的组织中，已经提出了TAS2R的保护功能，类似于它们在舌头上作为毒性检测器的功能。但是，TAS2Rs也已在内部器官中发现，暗示了这些受体的其他作用，可能涉及尚未鉴定的内源性配体。目前的综述概述了口腔以外组织中TAS2R的不同提议功能;从食欲调节到哮喘的治疗，胃肠动力的调节和气道先天免疫的控制。

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