• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Behavioural pharmacology >Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.
【24h】

Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze.

机译：背外侧腹周围水管灰色N-甲基-D-天冬氨酸谷氨酸受体参与大鼠T-迷宫风险评估和抑制回避行为的调节。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The involvement of the dorsolateral periaqueductal gray in the regulation of fear-related behaviors such as escape and freezing is well established. It is still a matter of investigation, however, whether this midbrain area may have a relevant role in the modulation of more subtle defensive responses associated with anxiety such as risk assessment and inhibitory avoidance. By stimulating N-methyl-D-aspartic acid glutamate receptors located in the dorsolateral periaqueductal gray with its prototypical agonist N-methyl-D-aspartic acid (50 pmol), we report here an increase in both risk assessment and inhibitory avoidance behaviors of male Wistar rats tested in the elevated T-maze. These results are indicative of an anxiogenic-like effect. The selective N-methyl-D-aspartic acid receptor antagonist DL-2-amino-7-phosphonoheptanoic acid (2.0 and 4.0 nmol) had the opposite effect on both defensive tasks. Pretreatment with an ineffective dose of DL-2-amino-7-phosphonoheptanoic acid (1.0 nmol) prevented the N-methyl-D-aspartic acid anxiogenic-like effect. At the dose range of DL-2-amino-7-phosphonoheptanoic acid and/or N-methyl-D-aspartic acid tested, neither the escape response from one of the elevated T-maze open arms nor the general exploratory activity as assessed in the open-field test was affected. The present results suggest that the dorsolateral periaqueductal gray column is also involved in the regulation of defensive behaviors related to anxiety, and N-methyl-D-aspartic acid glutamate receptors are recruited for this action.
机译：背侧周围导水管灰色参与了与恐惧相关的行为的规制，例如逃跑和冰冻。但是，这个中脑区域是否可能在调节与焦虑相关的更微妙的防御反应（例如风险评估和抑制性避免）中起相关作用，这仍是一个调查问题。通过使用原型激动剂N-甲基-D-天冬氨酸（50 pmol）刺激位于背外侧周导水道灰色的N-甲基-D-天冬氨酸谷氨酸受体，我们在此报告男性的风险评估和抑制回避行为均增加Wistar大鼠在升高的T型迷宫中测试。这些结果表明了类似焦虑的作用。选择性的N-甲基-D-天冬氨酸受体拮抗剂DL-2-氨基-7-膦基庚酸（2.0和4.0 nmol）对两种防御任务都具有相反的作用。用无效剂量的DL-2-氨基-7-膦基庚酸（1.0 nmol）进行预处理可防止N-甲基-D-天冬氨酸类似血管生成的作用。在测试的DL-2-氨基-7-膦基庚酸和/或N-甲基-D-天门冬氨酸的剂量范围内，既没有从升高的T形迷宫张开臂之一逃逸的反应，也没有评估了在野外测试受到影响。目前的结果表明，背外侧导水管周围的灰色柱体也参与了与焦虑相关的防御行为的调节，为此，N-甲基-D-天冬氨酸谷氨酸受体被募集。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号