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首页> 外文期刊>American Journal of Sports Medicine >Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model.
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Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model.

机译：胶原蛋白-血小板复合材料可改善猪模型中愈合的前交叉韧带移植物的生物力学性能。

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BACKGROUND: The outcome of anterior cruciate ligament (ACL) reconstruction is variable, and many patients have increased joint laxity postoperatively. HYPOTHESIS: Placement of a collagen-platelet composite (CPC) around the graft at the time of ACL reconstruction decreases postoperative knee laxity and improves the structural properties of the graft compared with standard ACL reconstruction. STUDY DESIGN: Controlled laboratory study. METHODS: Thirteen immature pigs underwent unilateral ACL reconstruction with a bone-patellar tendon-bone allograft. In 6 pigs, a standard allograft was used to reconstruct the ACL. In 7 pigs, a CPC was placed around the allograft. After 15 weeks of healing, the animals were euthanized, and the anterior-posterior (AP) knee laxity and structural properties of the graft were measured. Qualitative histology of the grafts was also performed. RESULTS: The AP laxity values of the reconstructed knees, normalized to the contralateral control, were significantly reduced by 28% and 57% at 60 degrees and 90 degrees of knee flexion, respectively, with the addition of CPC (P < .001). Significant improvements in the graft structural properties were also found; the normalized yield (P = .044) and maximum failure loads (P = .025) of the CPC group were 60% higher than the standard ACL-reconstructed group. Although cellular and vessel infiltration were observed in the grafts of both groups, regions of necrosis were present only in the standard ACL-reconstructed group. CONCLUSION: These data demonstrate that the application of CPC at the time of ACL reconstruction improves the structural properties of the graft and reduces early AP knee laxity in the porcine model after 15 weeks of healing. CLINICAL RELEVANCE: Application of a CPC to an ACL graft at the time of surgery decreased knee laxity and increased the structural properties of the graft after 15 weeks of healing.
机译：背景：前交叉韧带（ACL）重建的结果是可变的，许多患者术后关节松弛度增加。假设：与标准ACL重建相比，在ACL重建时将胶原蛋白-血小板复合材料（CPC）放置在移植物周围可减少术后膝关节松弛，并改善移植物的结构特性。研究设计：受控实验室研究。方法：13只未成熟的猪接受了pat骨肌腱-骨同种异体移植的单侧ACL重建。在6只猪中，使用标准同种异体移植物重建ACL。在7头猪中，将CPC放置在同种异体移植物周围。愈合15周后，对动物实施安乐死，并测量了前后（AP）膝关节的松弛度和移植物的结构特性。还进行了移植物的定性组织学检查。结果：加上CPC，在60度和90度屈膝时，经对侧对照标准化的重建膝关节的AP松弛度分别显着降低了28％和57％。还发现了移植物结构性能的显着改善; CPC组的标准化屈服（P = .044）和最大破坏载荷（P = .025）比标准ACL重建组高60％。尽管在两组的移植物中均观察到细胞和血管浸润，但仅在标准ACL重建组中存在坏死区域。结论：这些数据表明，在ACL重建时应用CPC可以改善猪模型在愈合15周后的结构性能，并减少早期AP膝关节松弛。临床相关性：在手术时将CPC应用于ACL移植物可减少膝关节松弛，并在愈合15周后增加移植物的结构特性。

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